1 / 19

1998 Nobel Prize: Discoveries on Nitric Oxide as a Signaling Molecule in Cardiovascular Health

In 1998, the Nobel Prize in Physiology or Medicine was awarded for groundbreaking discoveries about nitric oxide (NO) as a crucial signaling molecule in the cardiovascular system. Robert F. Furchgott, Ferid Murad, and Louis J. Ignarro were recognized for their work revealing how nitric oxide regulates blood flow and pressure, impacts smooth muscle relaxation, and plays a vital role in conditions like angina and atherosclerosis. Their research has significantly enhanced our understanding of vascular biology and disease mechanisms, establishing nitric oxide’s importance in pharmacology and human health.

jamil
Télécharger la présentation

1998 Nobel Prize: Discoveries on Nitric Oxide as a Signaling Molecule in Cardiovascular Health

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. The Nobel Prize1998for their discoveries concerning nitric oxide (NO) as a signaling molecule in the cardiovascular system B9503207陳又嘉 B9503212林佳美 B9503225葉佳宜 B9503230王馥陞B9503232蕭名傑 B9503233張益嘉 B9403232張瑜顯

  2. (1.) Robert F.Furchgott 1980 年自然期刊 (Nature) EDRF 內皮衍生之舒張因子 (endothelium-derived relaxing factor )

  3. (2) Ferid Murad • 1977 年環核甘酸研究期刊 (J Cycl Nucl Res) • 硝化甘油是經由釋放NO而使得血管平滑肌放鬆的

  4. (3) Louis J Ignarro • 1987年12月的美國國家科學院學報(Proc. Natl. Acad. Sci. USA) • prove that EDRF = NO

  5. NO in our life 1. air pollution 2. acid rain The function of NO 1. a signal passing material in never system 2. regulate blood pressure and the flow of blood

  6. (1) Furchgott acetylcholine EDRF

  7. (2) Murad • NO=========guanylate cyclase activatio • GTP=========cGMP guanylate cyclase

  8. (3) Louis J Ignarro Spectrophotometry Hemoglobin (yellow) exposed to endothelial cells that were stimulated to produce EDRF (green) Hemoglobin (yellow) directly exposed to NO (green)

  9. NO working mechanism

  10. Acetylcholine stimulates the endothelial cells to produce a factor, NO, which penetrates into and activates the muscle cells causing relaxation.

  11. (I) 血管內皮

  12. 控制一氧化氮製造量是調節一氧化氮活性的關鍵控制一氧化氮製造量是調節一氧化氮活性的關鍵 • 精胺酸 • 酶 (NOS) 抑制劑

  13. (II) 神經突觸

  14. For cardiovascular system • coronary artery • 冠狀動脈 • smooth muscle cells • 平滑肌細胞

  15. atherosclerotic coronary artery. • 冠狀動脈粥狀硬化 • angina pectoris • 心絞痛

  16. Nitroglycerin 硝化甘油

  17. 參考資料 • 1. http://www.medlib.ncku.edu.tw/people/1998.html2. http://www.tainandoctor.com/works_05.htm3. http://www.mednobel.ki.se/4. http://www.nobel.se/medicine/laureates/1998/illpres/enzyme.html5. http://www.nobel.se/medicine/laureates/1998/illpres/spectral.html6. http://www.nobel.se/medicine/laureates/1998/illpres/sandwich.html7. http://www.nobel.se/medicine/laureates/1998/illpres/index.html8. http://www.nobel.se/medicine/laureates/1998/illpres/medicine.html9. http://www.nobel.se/medicine/laureates/1998/illpres/application.html10.http://www.nobel.se/medicine/laureates/1998/press.html11.http://www.nobel.se/medicine/laureates/1998/medanim/images.html12.http://www.nobel.se/13.http://nobelprize.com/14.http:// www.infoplease.com/ipa/A0777579.html/15.http://www.accessexcellence.org/WN/SU/SU102001/nobelbio.html16.http://www.britannica.com/nobel/ 17.http://brc.se.fju.edu.tw/nobelist/199x/p1998.htm 18.http://www.biol.ntnu.edu.tw/doc/bill.htm

More Related