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Ralph H. B. Benedict, Ph.D., ABPP-CN Associate Professor of Neurology and Psychiatry SUNY Buffalo School of Medicine Jac

Outline. Brief HistoryUpdate: Screening for NP dysfunctionUpdate: Consensus NP Test BatteryClinical Application: Integrating Cognitive Assessment into Routine Care. MS: MRI T2 . Grade 1. Grade 2. Grade 3. . . . . . . . . . . . . Adapted from Rao et al. (1991). Language. SpatialAbilities. AttentionSpan.

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Ralph H. B. Benedict, Ph.D., ABPP-CN Associate Professor of Neurology and Psychiatry SUNY Buffalo School of Medicine Jac

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    1. Ralph H. B. Benedict, Ph.D., ABPP-CN Associate Professor of Neurology and Psychiatry SUNY Buffalo School of Medicine Jacobs Neurological Institute

    2. Outline

    3. MS: MRI T2

    5. NP Profiles in MS Comment on “subcortical dementia” concept – implies distinct and homogeneous patternComment on “subcortical dementia” concept – implies distinct and homogeneous pattern

    7. Brain tissue volume (contour – CSF) Outer contour of brain surface

    13. Screening for MS Cognitive Impairment using a Self-Administered 15-Item Questionnaire Benedict et al. Multiple Sclerosis. 2003; 9:95-101

    14. easily distracted lose focus when listening slowed problem solving trouble describing programs recently watched forgetting appointments forgetting what is read instructions repeated reminded to do tasks forgetting errands difficulty answering questions difficulty tracking two things at once missing the point of conversations difficulty controlling impulses laugh/cry with little cause talk excessively MS Neuropsychological Screening Questionnaire (MSNQ)

    15. Screening for MS Cognitive Impairment Using a Self-Administered 15-Item Questionnaire

    16. Bayesian Probabilities, Informant Report MSNQ

    17. Problems?

    18. MSNQ Cross Validation - Methods

    19. MSNQ Cross Validation - Reliability

    20. MSNQ Cross Validation - Validity

    21. MSNQ Cross Validation – Predictive Validity

    24. Process:

    25. Consensus: Psychometric Criteria

    26. Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS)

    27. Practice Effects, Alternate Forms

    28. Brief Visuospatial Memory Test - Revised

    29. MACFIMS Validation

    32. Study Design

    33. Regression Analysis Results

    35. Neuropsychological Practice Guidelines

    38. Thank You

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