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Adult Medical-Surgical Nursing

Adult Medical-Surgical Nursing. Renal Module: Acute Renal Failure. Acute Renal Failure: GFR. The glomerular filtration rate (GFR) indicates the efficiency of the kidney nephrons: In concentrating urine to excrete toxins from the body In maintaining water and electrolyte balance in the body

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Adult Medical-Surgical Nursing

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  1. Adult Medical-Surgical Nursing Renal Module: Acute Renal Failure

  2. Acute Renal Failure: GFR • The glomerular filtration rate (GFR) indicates the efficiency of the kidney nephrons: • In concentrating urine to excrete toxins from the body • In maintaining water and electrolyte balance in the body • Average urine output is approximately 1500 ml/ 24 hours

  3. Acute Renal Failure: Classification • A sudden decrease in the glomerular filtration rate (occurring in hours to days) • Oliguria: < 400ml urine output in 24 hours • Anuria: < 50 ml in 24 hours • There may be normal volume but failure to concentrate urine therefore inability to rid the body of waste products • Urine output should be at least 30ml/ hour (400 ml/24 hours) in order to excrete metabolic waste

  4. Acute Renal Failure: Causes • Pre-renal (60% of cases) • Acute Tubular Necrosis (35-40%) • Post-renal (5%)

  5. Acute Renal Failure:Pre-renal Causes (Hypoperfusion) • Pre-renal: hypoperfusion of the kidneys. Impaired blood flow leads to ↓ GFR and urine output • Caused by: • Hypovolaemia (haemorrhage, burns, diarrhoea and vomiting) • Impaired cardiac function • Vasodilation (anaphylactic or septic shock)

  6. Acute Renal Failure: Acute Tubular Necrosis • Direct trauma or toxicity to kidney tissue (nephrons: glomeruli, tubules) from: • Burns } myoglobin from muscle • Crush injuries • ABO incompatibility (agglutination RBCs) • Drugs: including nephrotoxic chemotherapy • Severe infections/ auto-immune reactions: pyelonephritis/ glomerulonephritis

  7. Acute Renal Failure: Post-renal Causes • Obstruction to urine flow in the renal tract leads to back-pressure, progressing to hydronephrosis and ↓ GFR. Caused by: • Tumours • Strictures • Calculi (stones) • Clots • Prostatic hyperplasia

  8. Acute Renal Failure:Four Clinical Phases • Initiation phase: from time of insult to oliguria (hours to days) • Oliguric period: Period of most clinical manifestations and abnormal kidney function tests (KFT) (10-20 days but may be months) • Diuresis: ↑ urine output but urine may be mostly water. Risk of dehydration. Symptoms/ KFT begin to improve (2-3 weeks) • Recovery: Symptoms/ KFT improved (3-12 months)

  9. Acute Renal Failure: Outcome • Recovery is possible but may not be complete: GFR 1-3% below normal • 50% of patients do not recover: acute renal failure may result in death or chronic renal failure

  10. Acute Renal Failure: Effects Failure of kidney function causes: Reduced urine volume, fluid retention, circulatory overload, ↑ BP Reduced urine concentration and excretion of toxic waste products of metabolism, most significantly: Raised blood urea/ creatinine Raised potassium: dysrhythmias Acidic substances: metabolic acidosis

  11. Acute Renal Failure: Clinical Manifestations • Reduced urine output • Weight gain and oedema; hypertension • Lethargy, drowsiness, sleep disturbance, convulsions, coma • Nausea, vomiting, cramps, diarrhoea • Hiccoughs, muscle twitching, restlessness • Cardiac dysrhythmias • Hyperventilation (acidosis) • Dry skin/ mucous membranes, fetor on breath

  12. Acute Renal Failure: Diagnosis • History and clinical picture • Oliguria • Altered KFT: • Raised blood urea, creatinine, potassium, uric acid, phosphates • Low serum calcium • Changes in urine specific gravity • ↑ urine sodium, cellular debris, RBC, WBC, casts • Metabolic acidosis (basal deficit; bicarb ↓)

  13. Acute Renal Failure:Clinical Management • Treat the cause • Support the patient (ICU) until recovery by: • Dialysis (usually via temporary central line) • Ventilation if necessary • Strict fluid intake restriction • Foley catheter • Diuretics to stimulate kidney function • Monitor for dysrhythmias and overload • Medications

  14. Acute Renal Failure:Nursing Considerations • Care in ICU; on ventilator if necessary • Continuous ECG monitoring • Monitor BP, JVP, oedema (overload) • Strict monitoring of intake/ output • Care of Foley catheter; hourly output (report <30ml) • Monitor progress through general condition, urine output, lab tests • Support relatives

  15. Acute Renal Failure: Medications • Diuretics: stimulate renal function • Insulin and Dextrose } ↓ high blood • Kayexalate potassium level • Calcium Gluconate • Sodium Bicarbonate: correct acidity • Aluminium hydroxide } correct • Calcium carbonate phosphate/ calcium levels

  16. Acute Renal Failure: Follow-up • Diet: Fluid restriction • Increased CHO (protein-sparing) • Reduced protein initially • Reduced potassium-containing foods • Reduced medication doses as toxic • Monitor progress: urine output, weight, BP, KFT • Monitor for anaemia: erythropoietin ↓

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