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lenalid 5mg capsule

Lenalid 5 mg Capsule (lenalidomide ) is used to treat anemia, which occurs in patients suffering from myelodysplastic syndrome (MDS)@ myapplepharma

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lenalid 5mg capsule

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  1. LENALID 5MG CAPSULE(lenalidomide )

  2. The indications ofLenalid 5mg are; Lenalid( lenalidomide) combination with dexamethasone is indicated to treat the patients suffered from multiple myeloma, the main ingredient which is used as lenalidomide.Lenalid5mg capsule is indicated for the patients having transfusion-dependent anemia because of intermediate 1 risk myelodysplastic syndrome along with deletion 5q cytogenetic abnormality without or without addition cytogenetic abnormalities Lenalid( lenalidomide) is used to treat the patients with mantle cell lymphoma in which its used whose the disease was relapsed or progressed after two before treatment, especially the disease not response with the bortezomib therapy.

  3. MECHANISM • Lenalid 5mg involves in the prudence of tumor and factor alpha arrangement, thatreinforcement the T-cells and leads to lessening plasma levels of cytokines vascular endothelial growth factor and fundamental fibroblast growth factor.Lenalid5mg capsule is moreover engaged with the stave off angiogenesis. Lenalidomideis furthermoreauthorize G1 cell cycle capture and apoptosis of ruinous cells.

  4. MECHANISM • Lenalid 5mg involves in the prudence of tumor and factor alpha arrangement, thatreinforcement the T-cells and leads to lessening plasma levels of cytokines vascular endothelial growth factor and fundamental fibroblast growth factor.Lenalid5mg capsule is moreover engaged with the stave off angiogenesis. Lenalidomideis furthermoreauthorize G1 cell cycle capture and apoptosis of ruinous cells.

  5. The adult usual dose of Lenalid( lenalidomide) 5mg in myelodysplastic syndromes is 10mg and adminisrated once a day. For renal damaged patients; CrCl>60ml/minIn Patients should not needed dosage adjustment of LenalidCrCl 30 to 60ml/minIn Patients, 5mg of Lenalid( lenalidomide) should administre orally as once daily CrCl<30ml/minIn Patient, 2.5mg of Lenalid should be given orally as a once daily. Dosage variation; Thrombocytopenia: Drops to <50000/mcL, treatment should be interrupted. Back to > or equal to 50000/mcL, follow the Lenalid( lenalidomide) of 5mg per day. Neutropenia; Drops to <500/mcL, treatment should be delayed. Back to > or equal to 500/mcL, treatment should be follow to 5mg per day. 

  6. PHARMACOKINETICS • Absorption: absorbed rapidly withpeak plasma concentration is between 0.625 and 1.5 hrs. combining with food will not change the prolong of absorption but dose decrease in Cmax.  • Distribution: bounding of plasma protein is 30%  • Metabolism: mainly metabolized in two metabolites is hydroxy-lenalidomide and N-acetyl-lenalidomide. Excretion: primarily eliminated in renal route and the dose excreted via urine 90% and feces 4% and half-life is 3hrs

  7. MANTLE CELL LYMPHOMA • Mantle cell lymphoma The usual dose of Lenalid( lenalidomide) for this disease is 25mg should be given orally as once daily. For renal damaged patients; CrCl 30 to 60ml/min in patient,Lenalid 5mg capsule price in indiashould be given as once daily. CrCl<30ml/min in patients, Lenalid( lenalidomide) 15mg should be used for q48hr. Pediatrics; The safety&efficiency of Lenalidomide has not been decribed in pediatric patients with age of <18 years.

  8. DRUG INTERACTION • Interaction of Lenalid( lenalidomide) 5mg with digoxin leads to increased concentration of digoxin causes increased risk of adverse effects related to digoxin. Interaction of Lenalid5mg capsule with Erythropoietic agents, cause to produced rises in risk of thrombosis. Discuss with the patients prior to starting this combination treatment. Interaction of Lenalid( lenalidomide) 5mgwith warfarin, will produce increased exposure of hemorrhage disorders. check the INR value & prothrombin time.

  9. OVER DOSAGE • Over dosage of Lenalid( lenalidomide) 5mgwill cause neutropenia& thrombocytopenia as mainly common side effects. Give the patient general supportive treatment. check the blood cells counts regularily during the treatment.

  10. MISSED DOSE • The missed dose of Lenalid capsule ( lenalidomide) 5mg should be avoided. If missed dose founded, then patients should be consulting with doctor specialized in oncologist Regulate theusual dosing schedule.

  11. CONTRAINDICATION • When pregnancy period the drug is contraindicated The patients are contraindicated to hypersensitivity reaction and the Lenalid 5mg ( lenalidomide) 5mg component.

  12. CONTACT US • Phone Number +91-9987711567 • Email ID applepharmaceutical@gmail.com • Address Apartment No.304 A Wing, Shiva Shakthichs ltd, JP Road, Near ApnaBazar,Andheri(West),Mumbai - 400058.Maharashtra

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