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Viekira Pak R

Viekira Pak R. Paritaprevir / Ritonavir / Ombitasvir / Dasabuvir. ( Viekira Pak R ) 4 VIR ( PROD ) P aritapre vir R itona vir O mbitas vir D asabu vir. custo-efetividade por pessoa tratada.

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Viekira Pak R

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  1. ViekiraPakR

  2. Paritaprevir/Ritonavir /Ombitasvir/ Dasabuvir • (ViekiraPak R ) • 4 VIR ( PROD ) Paritaprevir Ritonavir Ombitasvir Dasabuvir

  3. custo-efetividade por pessoa tratada • Em comparação ao tratamento com interferonpeguilado e ribavirina (PR), e um inibidor da protease para o genótipo HCV (G) 1 e sozinho PR para G2 / 3 , o tratamento com PR e sofosbuvir (PRS) para G1 / 4 e tratamento com sofosbuvir e ribavirina ( SR ) para o G2 / 3 aumentou QALYs por 555 226, mortes reduziu em 80 682, e aumentou os custos em 26,2 bilhões dólares em um ICER de 47 $ 304 por QALY ganho . • Em comparação com PRS / SR , tratando todos com um regime oral de sofosbuvir e Simeprevir (SS) para G1 / 4 e SR para G2 / 3, aumentou QALYs por 1 110 451 e reduziu as mortes por um adicional de 164 540 a um custo incremental de 80.100 milhões dólar e um ICER de US $ 72 169. na análise de sensibilidade , onde o tratamento com SS eficácia foi definida como o preço de lista de ViekiraPak e depois Harvoni , o tratamento custa 24 $ 921 e US $ 25 405 por QALY ganho em relação ao PRS / SR . • CONCLUSÕES: Novos tratamentos são de custo-efetividade por pessoa tratada , mas a demanda reprimida por tratamento pode criar desafios para financiamento.

  4. Dosing • Twoombitasvir, paritaprevir, ritonavir 12.5/75/50 mgtabletsoncedaily • (in themorning) +  • Onedasabuvir 250 mgtablettwicedaily (morningandevening) with a mealwithoutregard to fatorcaloriecontent. • Ifribavirin is prescribed, thentaketheprescribed dose, usually 1000 mg - 1200 mg (weight-dependent). • The dose is dividedandtakentwicedailywithfood. • A daily dose of 1200 mg = 6 pills, whichmeanstakingthreepills, two times daily. 

  5. Genotype 1b, no cirrhosis - TakeViekiraPak for 12 weeks • Genotype 1b, cirrhosis - TakeViekiraPak + ribavirin for 12 weeks • Genotype 1a, no cirrhosis - TakeViekiraPak + ribavirin for 12 weeks • Genotype 1a, cirrhosis - TakeViekiraPak + ribavirin for 24 weeks • HCV/HIV coinfection - followabove dose • Livertransplantrecipientswith normal hepaticfunctionandmildfibrosis (Metavirfibrosisscore ≤2), therecommendeddurationofViekiraPakwithribavirin is 24 weeks.

  6. Genotype 1b, no cirrhosis - TakeViekiraPak for 12 weeks • Genotype 1b, cirrhosis - TakeViekiraPak + ribavirin for 12 weeks • Genotype 1a, no cirrhosis - TakeViekiraPak + ribavirin for 12 weeks • Genotype 1a, cirrhosis - TakeViekiraPak + ribavirin for 24 weeks • HCV/HIV coinfection - followabove dose • Livertransplantrecipientswith normal hepaticfunctionandmildfibrosis (Metavirfibrosisscore ≤2), therecommendeddurationofViekiraPakwithribavirin is 24 weeks.

  7. What does Viekira Pak cost? • The wholesale acquisition cost of • twelve weeks of Viekira Pak is $83,320, • plus the cost of ribavirin (around $2500 for 12 weeks). • Patients needing 24 weeks of treatment, with a price tag of • $167,640 plus the cost of ribavirin (around $5000 for 12 weeks).

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