Comprehensive Guide to Immune Disorders: Care and Nursing
Explore hypersensitivity reactions, autoimmune disorders, and immune deficiencies. Learn about anaphylaxis, transplant rejection, rheumatoid arthritis, and more. Understand symptoms, treatments, and nursing care for optimal patient management.
Comprehensive Guide to Immune Disorders: Care and Nursing
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Presentation Transcript
Chapter 19 Nursing Care of Patients with Immune Disorders
Disorders ofthe Immune System • Three Categories • Hypersensitivity Reactions • Autoimmune Disorders • Immune Deficiencies
Disorders of the Immune System (cont’d) • Hypersensitivity Reactions • Anaphylaxis • Hemolytic Transfusion Reactions • Measles • Transplant Rejections
Disorders of the Immune System (cont’d) • Autoimmune Disorders • Rheumatoid Arthritis • Ulcerative Colitis • Multiple Sclerosis
Disorders of the Immune System (cont’d) • Immune Deficiencies • Hypogammaglobulinemia • Acquired Immunodeficiency Syndrome
Hypersensitivity Reactions • Injury to Body Due to Exaggerated Response • Classified by Way Tissue is Injured • Type I, II, III, IV
Type I • Anaphylactic Reaction • Immediately • Mild to Severe, Life-threatening
Allergic Rhinitis • Most Common Form of Allergy • Sneezing, Nasal Itching, Runny Nose, Itchy Red Eyes
Atopic Dermatitis • Eczema • Inflammatory Skin Response • Pruritus, Edema, Extremely Dry Skin, Blisters, Crusts, Scales
Anaphylaxis • Severe Systemic Hypersensitivity Reaction • Widespread Histamine Release • Bronchial Narrowing: Stridor, Wheezing, Respiratory Arrest • Hypotension, Tachycardia, Cardiac Arrest
Anaphylaxis (cont’d) • Immediate Treatment Guided by Symptoms • Oxygen • Epinephrine • Antihistamines • Corticosteroids • Vasopressors • Mechanical Ventilation
Anaphylaxis (cont’d) • Nursing Care • Early Recognition • Maintain Airway • Emotional Support • Education
Urticaria(Hives) • Release of Histamine • Raised, Pruritic, Non-tender, Erythematous Wheals on Skin
Urticaria(Hives)(cont’d) • Therapeutic Interventions • Epinephrine • Corticosteroids • Antihistamines • Histamine H2 Blockers
Angioedema • Form of Urticaria • Affects Submucosal/Subcutaneous Tissue Rather Than Skin • Painless, Dermal Erythematous/ Subcutaneous Eruptions, Skin/Mucous Membrane Edema
Type I Nursing Diagnoses • Impaired Gas Exchange • Anxiety • Risk for Impaired Skin Integrity • Ineffective Health Maintenance
Type I Nursing Care • Monitor Respiratory Status • Monitor Level of Consciousness • Stay with Patient • Provide Information • Note and Document Skin and Lesions • Teach Rubbing or Pressure, Not Scratching
Type I Nursing Care (cont’d) • Teach Patient to Wear Medical Alert Identification • Discuss Methods of Avoiding Allergen
Type II • Destruction of Substance with Antigen • May Be Beneficial (Bacteria) • Not Beneficial When RBC Sensed as Foreign
Hemolytic Transfusion Reaction • RBCs with Foreign Antigens Rapidly Lysed • Occludes Blood Vessels • Ischemia, Necrosis • Life-threatening
Hemolytic Transfusion Reaction (cont’d) • Prevention is Key! • Rhogam: Rho (D) Negative Patients • Careful Blood Transfusion Administration
Hemolytic Transfusion Reaction (cont’d) • Therapeutic Interventions • Antihistamines • Corticosteroids • Sympathomimetics
Hemolytic Transfusion Reaction (cont’d) • Nursing Diagnoses • Hyperthermia • Ineffective Tissue Perfusion • Impaired Gas Exchange • Ineffective Breathing Pattern
Hemolytic Transfusion Reaction (cont’d) • Nursing Care • Prevention • Careful Transfusion Monitoring • If Reaction, Stop Blood, Follow Policy • Education
Type III • Immune Complexes Formed by Antigens and Antibodies • Antigen-antibody Complexes Within Blood Vessels • Enzymes Lead to Blood Vessel Damage • Red Edematous Lesion, Bleeding, Necrosis
Serum Sickness • Antigen-antibody Complexes Cause Symptoms of Inflammation • 7 to 10 Days After Penicillin/Sulfonamide • Severe Urticaria and Angioedema • Brief and Self-limiting Condition
Serum Sickness (cont’d) • Nursing Diagnoses • Anxiety/Fear • Pain • Risk for Deficient Fluid Volume • Risk for Impaired Skin Integrity
Serum Sickness (cont’d) • Nursing Care • Monitor Symptoms • Evaluation Medication Effects • Education
Type IV • Delayed Reaction • Sensitized T Lymphocyte Contacts Antigen • Cell-mediated Immune Response • Necrosis
Contact Dermatitis • Chemical Comes in Contact with Skin • On Second Exposure, T Cells Secrete Chemicals • Poison Ivy, Poison Oak, Latex Rubber • Reddened, Pruritic, Fragile Vesicles
Contact Dermatitis (cont’d) • Therapeutic Interventions • Antihistamines, Topical Drying Agents, Corticosteroids • Tepid Baking Soda Baths or Aveeno Baths • Wash with Brown Soap (Fels-naptha) • Avoid Scratching Skin
Transplant Rejection • Transplanted Living Tissue Sensed as Foreign • Lymphocytes Sensitized Immediately • Invade Transplanted Tissue and Destroy it • Failure of Organ or Tissue • Infection Can Result in Death
Transplant Rejection (cont’d) • Prevention • ImmunosuppressionTherapy
Autoimmune Disorders • Immune System Recognizes Body’s Own Cells as Foreign • Immune Response Destroys Cells
Pernicious Anemia • Antibodies Against Gastric Parietal Cells and Intrinsic Factor • Vitamin B12 Deficiency • RBC Production Decreased • Also Caused by Gastric or Small Bowel Resections
Pernicious Anemia (cont’d) • Therapeutic Interventions • Corticosteroids • Lifelong Vitamin B12
Idiopathic Autoimmune Hemolytic Anemia • Autoantibodies Attach to RBCs • Lyse or Agglutinate
Idiopathic Autoimmune Hemolytic Anemia (cont’d) • Signs and Symptoms • Mild Fatigue • Pallor • Hypotension • Dyspnea • Jaundice
Idiopathic Autoimmune Hemolytic Anemia (cont’d) • Therapeutic Interventions • Immunosuppressive Medications • Oxygen • Corticosteroids • Folic Acid • Transfusion
Idiopathic Autoimmune Hemolytic Anemia (cont’d) • Therapeutic Interventions (cont’d) • Erythrocytapheresis • Splenectomy
Hashimoto’s Thyroiditis • Autoantibodies for Thyroid-stimulating Hormone, Thyroid Gland Overstimulation • Then Autoantibodies Destroy Thyroid, Hypothyroidism • Lifelong Thyroxine
Lupus Erythematosus • Three Types • Discoid (DLE) • Skin Lesions • Drug-induced Systemic Lupus Erythematosus • After Certain Medication Use • Systemic Lupus Erythematosus • Chronic, Inflammatory, Multisystem Disorder
Lupus Erythematosus (cont’d) • Etiology • Young Women of Child-bearing Years • First-degree Relatives of Lupus Patients • African American/Hispanic Population More Frequently
Lupus Erythematosus Signs and Symptoms • Discoid • Patchy, Crusty, Sharply Defined Skin Plaques • Occur on Face/Sun-exposed Areas
Systemic Lupus Erythematosus Signs and Symptoms • Drug-Induced • Pleuropericardial Inflammation • Fever • Rash • Arthritis
Systemic Lupus Erythematosus Signs and Symptoms (cont’d) • Early Symptoms Vague: Fatigue, Fever • Dermatologic: Butterfly Rash, Bruising Photosensitivity, Alopecia, Pain, Pruritis • Musculoskeletal: Arthralgia, Arthritis