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pH-Sensitive Biomaterials

pH-Sensitive Biomaterials. Patrick Hamilton, URI Biomedical Engeering. Order of Presentation. Introduction Polymers pH Sensitivity Targeted tumor removal How it is possible Pros and cons of the technology. Introduction. 2 main types of pH-sensitive molecules

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pH-Sensitive Biomaterials

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  1. pH-Sensitive Biomaterials Patrick Hamilton, URI Biomedical Engeering

  2. Order of Presentation • Introduction • Polymers • pH Sensitivity • Targeted tumor removal • How it is possible • Pros and cons of the technology

  3. Introduction • 2 main types of pH-sensitive molecules • Acidic (COOH or SO3H), which swell in a basic solution • Basic (NH2), which swell in an acidic solution • Change in pH is used in order to ionize the functional groups above in a polymer, or a very large molecule that has a repeating chain • When ionized, the release of whatever is contained within the polymer (usually medicine) can take place

  4. http://people.clarkson.edu/~ekatz/Signal-responsive7.jpg

  5. Targeted tumor removal • One function of these polymers right now is for use in targeted tumor treatment • By targeting the tumor from inside the body, medicine that could be harmful to healthy cells is better contained in the area that needs it

  6. Tumor removal (cont.) • During testing, they were able to show that in a more acidic solution (pH 6.0), the polymer would open up, thus releasing the GFP from inside, which could then be picked up by imaging software • Proof of concept for using this technology for drug delivery Study: Chang Yoon Moon, Joung-Woo Choi, DayanandaKasala, Soo-Jung Jung, Sung Wan Kim, Chae-Ok Yun, Dual tumor targeting with pH-sensitive and bioreducible polymer-complexedoncolytic adenovirus, Biomaterials, Volume 41, February 2015, Pages 53-68, ISSN 0142-9612, http://dx.doi.org/10.1016/j.biomaterials.2014.11.021.

  7. Ph-Sensitive Polymers Pros Cons • Much more targeted drug delivery than could be obtained than before • Less likely for poor side effects • Only in use for testing • Early stages of trial, not going to be commercially available for a bit • Every body is different

  8. Conclusion • pH sensitive polymers have the possibility to do great things for some terrible treatments by targeting the effected area • Even with this great promise, we are far off from any sort of regular implementation

  9. Questions? Thanks!

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