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No Wnt signaling

No Wnt signaling. ß-catenin recruitment and phosphorylation. ß-Trcp binding and ß-catenin degradation. Downstream gene expression inhibited. Wnt signaling. Activation of Disheveled and inhibition of ß-catenin degradation. Formation of LEF/TCF transcriptional complex.

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No Wnt signaling

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Presentation Transcript

  1. No Wnt signaling

  2. ß-catenin recruitment and phosphorylation

  3. ß-Trcp binding and ß-catenin degradation

  4. Downstream gene expression inhibited

  5. Wnt signaling

  6. Activation of Disheveled and inhibition of ß-catenin degradation

  7. Formation of LEF/TCF transcriptional complex

  8. Downstream gene expression activated

  9. Crosstalk between Wnts and other pathways

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