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Isotope R&D Facility

Isotope R&D Facility. A proposed addition to the HRIBF driver upgrade Mike Saltmarsh HRIBF Users’ Meeting Nov 13 th 2009. Proposed Isotope Production R&D Facility National Context. There is a national need for a reinvigorated DOE isotope program – selected recommendations from NSAC report

jeremy-fitzgerald
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Isotope R&D Facility

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  1. Isotope R&D Facility A proposed addition to the HRIBF driver upgrade Mike Saltmarsh HRIBF Users’ Meeting Nov 13th 2009

  2. Proposed Isotope Production R&D FacilityNational Context • There is a national need for a reinvigorated DOE isotope program – selected recommendations from NSAC report • “Support a sustained research program…. In the production and supply of isotopes….” • “Investment in new production capabilities” • “Investment in workforce development”

  3. Shared use of the C70 is unusually attractive • A substantial allocation of beam time to the isotope program would be available ( ~ 4500h/yr) • Little or no impact on the HRIBF mission or flexibility would be incurred • Concurrent construction of the isotope facility would not significantly impact the C70 upgrade construction • ORNL already has all the required isotope infrastructure from production through transportation • The incremental capital cost to the isotope program would be modest (7-10M$) • The opportunity to share operations costs would benefit both programs

  4. Elements of the proposed facility • Dedicated isotope target vault • Two beamlines from the C70 to the isotope vault • Two target stations, one a commercially available standard, the other compatible with the BNL/LANL target systems • Systems for remote transfer of the target modules from target station to transfer cell. • A transfer cell to package irradiated modules for transfer to the ORNL hot cells Items in red are part of the isotope facility Currently estimated total incremental cost is 7-10 M$

  5. Maximum power dissipation of target assembly (on blank copper target): 12 kW Beam profile on target: Gaussian 6 mm FWHM, rotated to uniform flat beam Angle of target face to beam: 6 degrees IBA Solid Target System Specifications

  6. Beams available from the C70

  7. Important Characteristics of the C70 and it’s anticipated operating regimes • Very high reliability (~ 95% for commercial C30) • Expectations for the HRIBF operating environment ~ 6600h/yr of extracted beam availability. 42 weeks, 156 h/week, 7 day operation. • Dual extraction capability for negative ion beams • HRIBF needs for RIB production ~ 4000 h/yr • Most RIB production (3000h/yr) requires the full energy proton beam at intensities 50 mA and higher • Allows simultaneous use of 70 MeV protons by isotope program. Independent intensity control (within limits) • HRIBF operation includes periods of days-weeks when C70 beams not required • 1500-2000 h/yr of dedicated beams (including alphas) available for the isotope program

  8. Elements of the Proposed Isotope Program would address many of the needs identified in the NSAC report • Radioisotope production R&D • New production regimes, eg for 225Ac • Excitation functions, thick target yields • Nuclear and radiochemistry • High power target design • Radioisotope Production • Research isotopes, eg 211At, 68Ge, 7Be • Commercial Isotopes, eg 82Sr, 68Ge • Education and Training

  9. Production R&D example • Short-lived (46 m) alpha emitter 213Bi offer great promise for radioimmunotherapy • Attach radionuclide to suitable antibody • Antibody preferentially attaches to tumor cell • Radiation delivered within ~100m of tumor cell, not elsewhere • Supplies are limited, hindering clinical trials • Currently source is 233U - 229 Th (7880y) - 225Ac (10d) as a generator for 213Bi • R&D required to investigate other possible production methods • Funded proposal to look at excitation functions and thick target yields for protons on 230Th and 232Th targets* at HRIBF • * garlandma@ornl.gov , stracenerdw@ornl.gov

  10. ORNL Infrastructure Available for Education and Training • Production R&D • Seek University partnerships • Training programs using ORNL facilities • Production facilities • Hot cells for target processing • Radiochemistry labs • Animal facilities • Transportation • Workshops • Workshop on next generation of radiochemists planned for spring 2010

  11. Shared use of the C70 is unusually attractive • A substantial allocation of beam time to the isotope program would be available ( ~ 4500h/yr) • Little or no impact on the HRIBF mission or flexibility would be incurred • Concurrent construction of the isotope facility would not significantly impact the C70 upgrade construction • ORNL already has all the required isotope infrastructure from production through transportation • The incremental capital cost to the isotope program would be modest (7-10M$) • The opportunity to share operations costs would benefit both programs

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