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Gametocytes fuse to form sporozoites in mosquito

Sporozoites enter The liver. Detoxified by heme polymerizase forming hemozoin. Mosquito infects human with plasmodium sporozoites upon biting. Sporozoites reproduce asexually and enter blood stream. Plasmodium multiply. Gametocytes fuse to form sporozoites in mosquito.

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Gametocytes fuse to form sporozoites in mosquito

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  1. Sporozoites enter The liver Detoxified by heme polymerizase forming hemozoin Mosquito infects human with plasmodium sporozoites upon biting Sporozoites reproduce asexually and enter blood stream Plasmodium multiply Gametocytes fuse to form sporozoites in mosquito Free heme is toxic In high concentrations Plasmodium (re)enters Red Blood Cells Gametes enter a new mosquito when it bites infected human Plasmodium cannot breakdown heme Red blood cells lyse releasing merozoytes Plasmodium digest Hemoglobin in the food vacuole Plasmodium reproduces asexually in red blood cells Some merozoites Develop into male & female gametocytes Heme from hemoglobin is released into the vacuole

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