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Original phantom

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  1. * • Poisson noise Scatter Non-uniform attenuation Detector response or point spread function (PSF) Tianfang Li Quantitative Reconstruction for Brain SPECT with Fan-Beam Collimators Nov. 24th, 2003 SPECT system: • Developing a fast and accurate reconstruction algorithm for single photon emission computed tomography (SPECT) • Compensates for Poisson noise, Compton scatter, collimator/detector response, and attenuation effects • Quantitative analysis with regional bias-variance plot, receiver operating characteristic (ROC) study, and Hotelling trace calculation • Verified with Monte Carlo simulations and compared with the widely used ordered-subset expectation maximization (OSEM) algorithm. Similar image quality is achieved with computational cost improved about 48 times. Filtered backprojection (FBP) reconstruction Original phantom OSEM reconstruction Reconstruction with proposed method

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