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Core 3.1 - Dartmouth Activities

NA-MIC National Alliance for Medical Image Computing http://na-mic.org. Core 3.1 - Dartmouth Activities. Andrew J. Saykin, Psy.D., ABPP-CN John D. West, M.S. Robert M. Roth, Ph.D. Brain Imaging Laboratory Dartmouth Medical School / DHMC . Overview. Volumetric ROI studies

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Core 3.1 - Dartmouth Activities

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  1. NA-MIC National Alliance for Medical Image Computing http://na-mic.org Core 3.1 - Dartmouth Activities Andrew J. Saykin, Psy.D., ABPP-CN John D. West, M.S. Robert M. Roth, Ph.D. Brain Imaging Laboratory Dartmouth Medical School / DHMC

  2. Overview • Volumetric ROI studies • Diffusion tensor imaging • ROI analyses • Tractography • Functional magnetic resonance imaging • Planned applications • Related work • Current Collaborations National Alliance for Medical Image Computing http://na-mic.org

  3. ROI Volumetric Studies • Manual Tracing and 3D Modeling of • ROIs using Slicer • ROIs: • Hippocampus • Amygdala • Entorhinal cortex • Caudate nucleus • Putamen • Nucleus accumbens • Thalamus • Fornix • Mammillary bodies National Alliance for Medical Image Computing http://na-mic.org

  4. ROI Volumetric Studies Illustration of 2D Traces and 3D Models of ROIs National Alliance for Medical Image Computing http://na-mic.org

  5. Diffusion Tensor Imaging FA in Uncinate Fasciculus ROI in Schizophrenia using Slicer Based on Kubicki et al., 2002 National Alliance for Medical Image Computing http://na-mic.org

  6. Diffusion Tensor Imaging Integration of Corpus Callosum Subregion ROIs with Tractography Healthy Control Patient with Schizophrenia C1 - rostrum and genu C2 - anterior truncus C3 - middle truncus C4 - posterior truncus C5 - isthmus and splenium [Wang et al. 2005] National Alliance for Medical Image Computing http://na-mic.org

  7. Functional MRI • Cognitive Task Development and Validation: Probing Frontal-Temporal Circuitry • Primary Tasks: • Working memory • Episodic memory • Semantic memory Secondary Tasks (other Circuitry) • Self-reflection • Reward • Planning National Alliance for Medical Image Computing http://na-mic.org

  8. Functional MRI Prospective Data Collection on 1.5T Magnet: Interim Analysis of Patients with Schizophrenia and Controls Controls Patients p (n=8) (n=13) Age (yrs.) 30.8 (7.1) 36.4 (10.3) NS Educ (yrs.)* 16.9 (2.4) 14.6 (1.9) .05 Sex (M,F) 3, 5 9, 3 NS WRAT Reading 111.5 (4.7) 105.0 (10.5) NS CVLT-II Total 1-5 58.4 (6.4) 38.6 (10.4) .001 * matched for parental SES National Alliance for Medical Image Computing http://na-mic.org

  9. Functional MRI n-Back Working Memory Task National Alliance for Medical Image Computing http://na-mic.org

  10. Functional MRI – Behavioral Performance Interim analysis National Alliance for Medical Image Computing http://na-mic.org

  11. Functional MRI FMRI Activation During 3-Back in Schizophrenia Simple Effects Controls N = 8 Patients N = 12 p = .01 Interim analysis National Alliance for Medical Image Computing http://na-mic.org

  12. Functional MRI FMRI Activation During 3-Back in Schizophrenia Controls > Patients Patients > Controls p = .01 Interim analysis National Alliance for Medical Image Computing http://na-mic.org

  13. Functional MRI Verbal Encoding/Retrieval Episodic Memory Task National Alliance for Medical Image Computing http://na-mic.org

  14. Functional MRI – Behavioral Performance Verbal Encoding/Retrieval Episodic Memory Task Interim analysis National Alliance for Medical Image Computing http://na-mic.org

  15. Functional MRI – Behavioral Performance Verbal Encoding/Retrieval Episodic Memory Task Interim analysis National Alliance for Medical Image Computing http://na-mic.org

  16. Functional MRI Verbal Encoding/Retrieval Episodic Memory Task FMRI Activation During Continuous Auditory-Verbal Memory (new > old word contrast) in Patients with Schizophrenia Patients N = 7 p = .01 Interim analysis National Alliance for Medical Image Computing http://na-mic.org

  17. Collaborations and Progress • Shape Analysis with UNC Group: Martin Styner, Guido Gerig • Hippocampal Shape - Dartmouth Data: SPHARM Left Mean Right Mean Overall Mean Skeleton-based subdivision http://www.na-mic.org/Wiki/index.php/Progress_Report:Shape_Analysis National Alliance for Medical Image Computing http://na-mic.org

  18. Collaborations and Progress • fMRI in Slicer – fMRIEngine - Wendy Plesniak and Haiying Liu • Met Dec. 14th, 2005 to discuss progress and future improvements to be made • Have supplied motor data from two controls to test results from module and compare with results from SPM2 • fMRI tasks – Brigham group • Porting of our tasks to BWH • Meeting with Marek Kubicki on Dec. 20th, 2005 to demonstrate our tasks and how we utilize them • Training session at BWH • Tara McHugh visited to get in depth training in Slicer for tracing structures – Dec. 1st, 2005 National Alliance for Medical Image Computing http://na-mic.org

  19. Collaborations and Progress • Working with Steve Pieper to test 64-bit Linux version of Slicer • Worked with Steve Pieper, Gordon Kindlmann, Xiaodong Tao, and Josh Snyder to convert Dartmouth DTI data to nrrd format and solve lingering orientation issues • DTI Path of Interest – MGH – David Tuch and Josh Snyder • Dartmouth request for tools to help relate DTI fiber tract pathways to connections in fMRI identified circuits • Collaboration to implement DTI Path of Interest Program at Dartmouth site • Successful initial results on NAMIC01 healthy control by both Josh Snyder at MGH and John West at Dartmouth • Plans: integrate functional ROIs derived from fMRI tasks National Alliance for Medical Image Computing http://na-mic.org

  20. DTI Path of Interest – Initial Results • Collaboration with David Tuch & Josh Snyder (MGH) • Description – program finds the optimal path between two or more ROIs using probability statistics • Implementation • C-code, Matlab and FSL scripts to generate optimal path • Slicer for visualization and tracing of input ROIs • Full implementation in Slicer as module is a future project • Initial results from NAMIC01 healthy control National Alliance for Medical Image Computing http://na-mic.org

  21. DTI Path of Interest – Initial Results Hippocampal ROI to Ventral Prefrontal ROI Uncinate Fasciculus National Alliance for Medical Image Computing http://na-mic.org

  22. DTI Path of Interest – Initial Results Receptive Speech Area ROI to Expressive Speech Area ROI Arcuate Fasciculus National Alliance for Medical Image Computing http://na-mic.org

  23. DTI Path of Interest – Initial Results Hippo ROI to Expressive Speech Area ROI Using Receptive Speech Area ROI as Guide Arcuate Fasciculus National Alliance for Medical Image Computing http://na-mic.org

  24. Planned Applications & Developments • Integration of fMRI and DTI data, including tractography (see tool “wish list”) • Effective and functional connectivity during cognitive tasks (see tool “wish list”) • Examine structural (ROI, DTI) and functional (fMRI) correlates of symptoms and cognition • Expand use of methods to other populations • bipolar disorder, OCD, MCI/AD, MS, TBI, epilepsy, other disorders National Alliance for Medical Image Computing http://na-mic.org

  25. Neuroimaging Research Center 3T Magnet National Alliance for Medical Image Computing http://na-mic.org

  26. Neuroimaging Research Center 3T Magnet National Alliance for Medical Image Computing http://na-mic.org

  27. Brain Imaging Laboratory: People FACULTY PIs (Psychiatry): • Laura A. Flashman, Ph.D. • Alan I. Green, M.D. • Thomas W. McAllister, M.D. • Brenna C. McDonald, Psy.D. • Robert M. Roth, Ph.D. • Andrew J. Saykin, Psy.D. • Heather A. Wishart, Ph.D. POST-DOCTORAL FELLOWS: • Howard Cleavinger, Ph.D. (Epilepsy) • Ellen Crouse, Ph.D. (MCI, chemotherapy) • Nancy Koven, Ph.D. (Schizophrenia) • Nadia Paré Ph.D. (MCI, ADNI) • Jo Cara Pendergrass, Ph.D. (Schizophrenia) KEY TECHNICAL COLLABORATORS: • Konstantinos Arfanakis, Ph.D. (DTI; IIT) • Fillia Makedon , Ph.D. (Computer Science) • James C. Ford, Ph.D. (Computer Science) • Li Shen, Ph.D. (CS, UMASS-Dartmouth) • Jason Moore, Ph.D. (Comp Genetics) BIL COORDINATOR • Heather Pixley, B.A. IMAGE ANALYSTS & SYSTEMS ADMIN: • John MacDonald, M.A. • Tara McHugh, M.A. • Paul Wang, B.A. • John West, M.S. STUDY COORDINATORS: • Mary Hynes, RN (TBI) • Ariel Rosen, B.A. (MS) NEUROSCIENCE TECHNICIANS: • Carrie Kruck, B.A. (chemotherapy) • Margaret Nordstrom, B.A. (MCI) RESEARCH MRI TECHNOLOGISTS: • Jorge A. Forero • Alice E. Davison National Alliance for Medical Image Computing http://na-mic.org

  28. Dartmouth Brain Imaging Laboratory December, 2005 National Alliance for Medical Image Computing http://na-mic.org

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