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Methodology of the CRYSTAL update

Methodology of the CRYSTAL update. Increase of statistical power by Doubling ascertainment rate for KRAS “samples”: 45%  89% Median time to follow-up increased by approx. 1.5 years - 161 events more in total KRAS wt-population: Event rates increased from 62.9%  79.6%.

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Methodology of the CRYSTAL update

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  1. Methodology of the CRYSTAL update • Increase of statistical power by • Doubling ascertainment rate for KRAS “samples”: 45%  89% • Median time to follow-up increased by approx. 1.5 years - 161 events more in total • KRAS wt-population: Event rates increased from 62.9%  79.6% OS data based on 45%of study population (n=540) OS update based on 89% of study population (n=1063) Van Cutsem E, et al. ECCO/ESMO Congress 2009; Abstract No: 6077

  2. CRYSTAL-Updated efficacy analysis in patients by KRAS mutation status *Van Cutsem E, et al. ECCO/ESMO Congress 2009; Abstract No: 6077

  3. CRYSTAL: Summary of efficacy in KRAS wt *Van Cutsem E, et al. ECCO/ESMO Congress 2009; Abstract No: 6077

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