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Exploration of Macrolactone Antibiotics and Glycolipid Antigens in Microbial Systems

This study examines the role of various macrolactone antibiotics, including erythromycin derivatives such as ERY and TAO, and their impact on microbial organisms like Thermus thermophilus and Deinococcus radiodurans. Additionally, it explores the immunogenic potential of specific glycosylated structures, such as lipopolysaccharides and triacylated glycolipids from Mycobacterium tuberculosis, and their interactions with immune receptors like TLR2. The findings provide insights into antibiotic efficacy and potential vaccine candidates.

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Exploration of Macrolactone Antibiotics and Glycolipid Antigens in Microbial Systems

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Presentation Transcript

  1. Kim’s assignment The Interns

  2. Macrolactone Antibiotics • ERY- Erythromycin A • Thermus thermophilus • ERN- Erythromycyclamine • Deinococcus radiodurans • TAO- Troleandomycin • Deinococcus radiodurans

  3. Anthracycline Derivatives • 44D- Disaccharide anthracycline • “unassigned” • DM2- Doxorubicin • E. coli • DM7- Idodoxorubicin • “unassigned”

  4. Lipopolysaccharides • XPX- phosphatidylinositol mannoside • Mouse • 4GH- galactosylceramide • Mouse • Z69- triacylated glycolipid TLR2 • Mycobacterium tuberculosis (expressed in E. coli)

  5. Blood group antigens • 2W7Y- composed of A2G, FUC, GAL • Blood group A trisaccharide • Streptococcus pneumoniae • 3EYV- FUC, GAL, GOL, NDG • Lewis Y antigen • Mouse, human

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