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Center for Biological Physics

This research explores the direct measurement of intermolecular forces that contribute to a physics-based understanding of molecular organization. It investigates how single molecules navigate through channels, emphasizing the role of forces in structuring soft materials, colloids, and large biomolecules. Additionally, the study includes the dynamics of viral DNA under pressure and presents a unified equation of state for flexible polymers. By integrating diverse theories and experimental techniques, this work aims to build a comprehensive physics framework for nanoscale particles and their interactions.

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Center for Biological Physics

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  1. Center for Biological Physics Lori Goldner, Jenny Ross Adrian Parsegian Direct measurement of intermolecular forces to build a physics of molecular organization Watching single molecules move through channels Theory of intermolecular forces organizing soft materials, colloids and large bio-molecules

  2. Viral DNA is under pressure that can drive infection: exploded virus and intact virus DNA spooled inside a virus A. Evilevitch,(2006). Bacteriophage T2 Kleinschmidt et al. (1962)

  3. Building a physics of forces and energies for nanometer-to-micrometer - size particles Equation of State: Osmotic pressure vs. DNA density, function of salt, temperature, etc.

  4. Unified equation of state for flexible polymers: Osmotic pressures of many sizes and concentrations fit with ONE parameter. Joel Cohen (Univ Pacific), Rudi Podgornik (Slovenia) To be part-time @UMass

  5. Transport through single ionic channels Current detection of single-molecule transit E(mV) _ I(pA) + 25 µm Detection 1 cm pA 70 µm 0 10 ms Current through channel 100 µm 2 nm Sergey Bezrukov, Philip Gurnev Building an apparatus in Hasbrouck next month

  6. Theory of intermolecular forces(electrostatics, electrodynamics, solvation, steric)example of single-walled carbon nanotubes Connection between dielectric spectra and van der Waals torques/forces. Rick Rajter, Rudi Podgornik, Roger French, Wai-Yim Ching, AP Under study DNA, Lipids (cell membranes), Proteins Xiangyun Qiu, Rudi Podgornik, to be working @UMass Jason DeRouchey, Don Rau, et al. at NIH (where I used to work)

  7. Thanks

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