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This cohort study examines the impact of invasive monitoring interventions in patients with severe sepsis and septic shock, with a focus on those presenting with hypotension or elevated lactate levels. Conducted in a large urban tertiary-care hospital's Emergency Department and Medical Intensive Care Unit, the study highlights hemodynamic monitoring parameters, including central venous pressure, mean arterial pressure, and continuous venous oxygen saturation. Results reveal a 30.5% in-hospital mortality rate among patients, emphasizing the challenges in managing severe sepsis and the complexities surrounding treatment protocols.
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Demographic Variables • Age • 64-68 • Gender • Male and female • Diagnosis • Sepsis or septic shock • Hypotension • Elevated lactate level
Research Design • Specific design of study • Cohort Study • Interventions • Use and insertion of invasive monitoring equipment in ED • Monitoring of hemodynamic parameters such as: • central venous pressure (CVP) • arterial pressure (MAP) • continuous venous oxygen saturation (ScvO2) • Group • Completed protocol • Failed to complete protocol
Sample and Setting • Setting • Large urban tertiary-care hospital • Emergency Department (ED) • Medical Intensive Care Unit (MICU) • Inclusion criteria • Patients admitted to the ED with severe sepsis and hypotension or elevated lactate level • Exclusion criteria • Refusal of central line insertion • Documented contraindication to central line insertion • Did not survive long enough to undergo 6 h of EGDT • Patients not a candidate for aggressive treatment
Sample and Setting (cont.) • Method used • Statistical method • Sample size • Independent-samples t test over both the 3-month and the 6-month period. • p value based on an independent-samples t test • Mortality rate • The eligible patients had an overall in-hospital mortality rate of 30.5% with a mean APACHE II score of 29. • Refusal to participate number and percentage • 2 patient refused CVP • 19 total did not meet criteria • Institutional review board • Rhode Island Hospital • Consent • Waived