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THE CITRIC ACID CYCLE

THE CITRIC ACID CYCLE. Kadek Rachmawati. The citric acid cycle = Kreb’s cycle = Tricarboxy- lic acid cycle a series of reactions that oxidized Asetyl-CoA Occur in Mitochondria To yield energy (ATP)

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THE CITRIC ACID CYCLE

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  1. THE CITRIC ACID CYCLE Kadek Rachmawati

  2. The citric acid cycle = Kreb’s cycle = Tricarboxy- • lic acid cycle a series of reactions that oxidized Asetyl-CoA • Occur in Mitochondria • To yield energy (ATP) • TCA cycle the final common pathway for the aerobic oxidation of carbohydrate, lipid and protein

  3. TCA cycle is common pathway for carbohydrate, lipid and protein

  4. TCA cycle pathway

  5. The function of TCA cycle : • 1. Oxidized of Acetyl CoA ATP ( 1 mol Acetyl CoA 12 mol ATP ) • 2. The citric acid cycle is AMPHIBOLIC : - it can oxidized to yield ATP - it is important in the provision of carbon skeletons for gluconeogenesis, fatty acid synthesis and interconversion of amino acid

  6. Vitamins play key roles of the Citric Acid Cycle • Four of the B vitamins are essential in the citric acid cycle : 1. Ribovlavin FAD 2. Niacin NAD 3. Thiamin TPP 4. Pantothenic acid CoA • The B vitamins are essential in energy yielding metabolism by dehydrogenase enzyme : - FAD 2 mol ATP - NAD 3 mol ATP

  7. INHIBITOR OF TCA CYCLE 1. Fluoroacetate • Condensation with CoA Fluoroacetyl-CoA • Condensation FluoroacetylCoA with Oxaloace- tate Fluorocitrate inhibit Akoni- tase enzyme accumulation of citrate • Fluoroacetate pesticide 2. Malonate suksinat dehydrogenase enzyme 3. Arsenite α-ketoglutarate dehydrogena- se enzyme

  8. Participation of TCA cycle in fatty acid synthesis from glucose

  9. Involvement of TCA cycle in transamination and gluconeogenesis

  10. REGULATION OF TCA CYCLE

  11. REGULATION OF TCA CYCLE

  12. REGULATION OF TCA CYCLE

  13. REGULATION OF TCA CYCLE

  14. Thank You

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