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Epigenetic Regulation by piwi-Associated DNA Methylation in Mammalian Germline

This lecture discusses the role of piwi-associated RNA and DNA methylation in the epigenetic regulation of the mammalian germline. Key concepts include the involvement of DNA methylation in early embryogenesis, stem cell differentiation, and genomic imprinting. The dynamics of DNA methylation, particularly during the development of the zygote and its effects on gene expression and cancer, are also explored. The lecture highlights significant studies that shed light on methylation processes and their implications for cellular function and development.

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Epigenetic Regulation by piwi-Associated DNA Methylation in Mammalian Germline

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  1. Lecture20– Epigenomics – Animals BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

  2. Epigenetic Regulation by piwi-associated DNA methylation in Mammalian Germline Bucher et al., (2012) Current Opinion in Plant Biology 15 (5): 503-510

  3. Animal piwi-RNA and DNA methylation In mammals, DNA methylation and demethylation are involved in diverse processes including: early embryogenesis stem cell differentiation genomic imprinting 75, 221, Mayer W, Niveleau A, Walter J, Fundele R, Haaf T. Demethylation of the zygotic paternal genome. Nature 2000; 403:501–502. Haaf T. Methylation dynamics in the early mammalian embryo: implications of genome reprogramming defects for development. Curr Top MicrobiolImmunol 2006; 310:13–22. Watanabe D, Suetake I, Tada T, Tajima S. Stage- and cell-specific expression of Dnmt3a and Dnmt3b during embryogenesis. Mech Dev 2002; 118:187–190. Latham T, Gilbert N, Ramsahoye B. DNA methylation in mouse embryonic stem cells and development. Cell Tissue Res 2008; 331:31–55. ReikW, Walter J. Genomic imprinting: parental influence on the genome. Nat Rev Genet 2001; 2:21–32. IderaabdullahFY, Vigneau S, Bartolomei MS. Genomic imprinting mechanisms in mammals. Mutat Res 2008; 647:77–85.

  4. Animal piwi-RNA and DNA methylation (cont) X chromosome inactivation silencing of repetitive elements 224. DNA methylation is also involved in regulating neuronal development and development of cancers 225, 226. Heard E, Disteche CM. Dosage compensation in mammals: fine-tuning the expression of the X chromosome. Genes Dev 2006; 20:1848–1867.Senner CE, Brockdorff N. Xist gene regulation at the onset of X inactivation. CurrOpin Genet Dev 2009; 19:122–126. Chen RZ, Pettersson U, Beard C, Jackson-Grusby L, Jaenisch R, DNA hypomethylation leads to elevated mutation rates. Nature 1998; 395:89–93.  Dulac C. Brain function and chromatin plasticity. Nature 2010; 465:728–735. Feinberg AP, Ohlsson R, Henikoff S, The epigenetic progenitor origin of human cancer. Nat Rev Genet 2006; 7:21–33. J.R., and Pikaard, C.S. 2011. Nature Reviews Molecular Cell Biology 12:483–492.

  5. Figure 1 The clonal genetic model of cancer. Feinberg AP et al. (2005) The epigenetic progenitor origin of human cancer Nat Rev gene.7: 21–33 doi:10.1038/nri1748

  6. Figure 2 The epigenetic progenitor model of cancer. Feinberg AP et al. (2005) The epigenetic progenitor origin of human cancer Nat Rev gene.7: 21–33 doi:10.1038/nri1748

  7. Genomic and epigenomicregualtion of adipose tissue inflammation in obesity Toubal et al. Trends in Endocrinology & Metabolism, 2013

  8. Genomic and epigenomicregualtion of adipose tissue inflammation in obesity Toubal et al. Trends in Endocrinology & Metabolism, 2013

  9. Genomic and epigenomicregualtion of adipose tissue inflammation in obesity Toubal et al. Trends in Endocrinology & Metabolism, 2013

  10. Genomic and epigenomicregualtion of adipose tissue inflammation in obesity Toubal et al. Trends in Endocrinology & Metabolism, 2013

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