1 / 5

Fructose Intolerance

Glycogen. Fructose Intolerance. Fructose. Lack of Pi Allosteric Inhibition by F-1-P. ATP. Glucose-6-P. Glucose. ADP. Fructose-1-P. 1 o Deficiency: F-1-P Aldolase. F-1,6-BP. Effects: F-1-P Pi Glycogenolysis Gluconeogenesis Blood Glucose

kaoru
Télécharger la présentation

Fructose Intolerance

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Glycogen Fructose Intolerance Fructose • Lack of Pi • Allosteric Inhibition by F-1-P ATP Glucose-6-P Glucose ADP Fructose-1-P 1o Deficiency: F-1-P Aldolase F-1,6-BP • Effects: • F-1-P • Pi • Glycogenolysis • Gluconeogenesis • Blood Glucose • Reducing sugar ( ) in urine DHAP + Glyceraldehyde DHAP G-3-P Pyruvate • Treatment: • Limit Fructose/Sucrose

  2. Myocardial Infarction Glycogen • 1o Problem- Lack of O2 • Block of aerobic metabolism (ETS) • Induction of anaerobic metabolism (Glycolysis) • Effects: • ATP • Creatine Phosphate • Glycogen • LDH • Lactate/Pyruvate • NADH/NAD GLYCOLYSIS Lactate Dehydrogenase (LDH) Glucose NADH Pyruvate Lactate NAD Acetyl CoA TCA CYCLE ETS O2 NADH FADH2 ATP H2O ADP + Pi CO2

  3. Alcohol Abuse Ethanol Acetaldehyde Acetate NADH NAD NADH NAD NADH/NAD • Effects: • NAD requiring reactions/ NADH forming reactions • Lactate/Pyruvate • Gluconeogenesis • Fatty Acid Oxidation • Glycerol-3-P • Blood Glucose • NAD to NADH Reactions: • G-3-P to 1,3 BPG (Glycolysis) • Lactate to Pyruvate (Glycolysis) • Glycerol-3-P to DHAP (Branch of Glycolysis) • Many others

  4. Glycogen Storage Disease (Type 1)Von Gierke’s Disease Glucose-6-P Phosphatase Glycogen Glucose Glucose-6-P Pi • Effects: • Glycogen • Blood Glucose • Free fatty acids • Triglycerides • Cholesterol • Uric Acid • Lactate • Low Glucose: • Glucagon • Phosphorylase Activity • Glycogen to Glucose-6-P

  5. Glucose-6-P Dehydrogenase Glucose-6-P Dehydrogenase 6-Phosphogluconate DH CO2 6-P-Gluconate Ribulose-5-P Glucose-6-P NADPH NADPH NADP NADP NADPH/NADP • Effects: • NADPH levels • Reducing Power • GSH/GS-SG • Free radical/Peroxides • Hemoglogin • Hemolytic Anemia • Lens

More Related