1 / 37

第十一章 抗原提呈细胞与抗原的处理及提呈

Th. 第十一章 抗原提呈细胞与抗原的处理及提呈. Epitope. MHC. Th. 掌握抗原提呈细胞、抗原加工和处理、抗原提呈的概念。 掌握三种专职的抗原提呈细胞的特点。 掌握内源性抗原和外源性抗原提呈的不同。. Capture and presentation of antigen. Adaptive Immune Responses Initiated by APC. tissue. DC. antigen. Draining lymphatics. Lymph nodes. Afferent lymphatics. cortex.

karen-nichols
Télécharger la présentation

第十一章 抗原提呈细胞与抗原的处理及提呈

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Th 第十一章 抗原提呈细胞与抗原的处理及提呈 Epitope MHC Th

  2. 掌握抗原提呈细胞、抗原加工和处理、抗原提呈的概念。掌握抗原提呈细胞、抗原加工和处理、抗原提呈的概念。 掌握三种专职的抗原提呈细胞的特点。 掌握内源性抗原和外源性抗原提呈的不同。

  3. Capture and presentation of antigen Adaptive Immune Responses Initiated by APC tissue DC antigen Draining lymphatics Lymph nodes Afferent lymphatics cortex Efferent Lymphatics

  4. 第一节 抗原提呈细胞的特点Antigen -presenting cell 抗原提呈细胞(APC)是指能够加工、处理抗原并将抗原信息提呈给T淋巴细胞的一类细胞，在机体的免疫识别、免疫应答与免疫调节中起重要作用。

  5. Discovery of antigen-presenting cells and their role in immune response

  6. 专职抗原递呈细胞（Professional APC） --- express MHC-II and costimulator（共刺激分子） DC, Macrophage, B cell 非专职抗原递呈细胞（Professional APC） --- express MHC-II and costimulator by induced 内皮细胞 Endothelial cell 靶细胞 （Target cell） --- express MHC-I and costimulator Endogenous antigens （内源性抗原）

  7. 一、树突状细胞Dendritic cells （一）分类与特点

  8. Puripotent stem cell Myeloid progenitor Lymphoid progenitor Neutrophils 髓样DC Myeloid DC Monocytes NK cell 淋巴样DC Lymphoid DC T cell B cell Myeloid DC Macrophage 1. 根据来源的分类 Dendritic cells are derived from different lineages

  9. 2 根据分化成熟状态的分类

  10. 表面标志Surface markers FcR, CR, TLR High express of MHC, and costimulator (CD1a, CD83) 不成熟 成熟

  11. Dendritic Cell Maturation

  12. 3. 根据组织分布的分类 (1) 淋巴样组织中: 并指状（Interdigitating） DC (IDC)：T细胞区 (T cell zoon) 滤泡样（Follicular） DC (FDC)： 生发中心(germinal centre) (2) 非淋巴样组织中: 朗汉斯细胞（Langerhans cell）: 表皮,　肠道黏膜上皮 间质性DC: 非淋巴组织 (3) 体液 血液DC (Peripheral blood DC): 隐蔽细胞（Veiled cell）：输入淋巴管(afferent lymphatic)

  13. Langerhan’s cells 朗汉斯细胞 Langerhans cells found in the epidermis (skin) and mucous membranes (left). After capturing antigen in the tissues by phagocytosis or by endocytosis. DC migrate into the blood or lymph and circulate to lymphoid organs, become IDC（right）。

  14. 并指状Interdigitating DC (IDC） IDC express high levels of MHC molecules, and are more potent antigen-presenting cells than others

  15. 滤泡样Folicular DC（ FDC） FDC 不表达MHC 高表达FcR，C3bR FDC B cells

  16. (二) 功能 抗原提呈与免疫激活作用

  17. 二、单核-巨噬细胞 (1) 来源和分布 Self-renewing stem cell Bone marrow---Hemotopoietic stem cells

  18. Self-renewing stem cell Lymphoid progenitor Myeloid progenitor Puripotent stem cell Granulocyte-monocyte CPU Neutrophils monocyte Blood Tissue

  19. (2) 表面标志（Surface marks of macrophages） complement 3 antibody Surface receptor on macrophage CD11b/CD18 CD16 （FcR III） 4 1 LPS scavenger TCR MHC B7-2 CD28 CD64 （Fc  R I） CD35 （CR1） 2 CD32 （Fc  R II） antibody complement antibody

  20. Adherence of bacteria via receptors

  21. (3) 抗原加工和递呈（Antigen processing and presentation by macrophages）

  22. 三、 B 淋巴细胞

  23. 第二节 抗原的处理和提呈

  24. 抗原加工（Antigen processing） The conversion of native proteins to MHC-associated peptide fragments by APCs is called antigen processing.

  25. TC (CTL) TCR CD8 MHC-I MHC-II CD4 TCR 抗原提呈 （Antigen presentation ） APCs convert protein antigens to peptides, and they display peptide-MHC complexes for recognition by the T cells. Th1

  26. 根据来源不同将抗原分为 内源性抗原（ Endogenous antigens）: generated within the Cells 外源性（Exogenous antigens）: taken up by cells (endocytosis)

  27. Antigen uptake 抗原的摄取

  28. (A) 胞吞作用 (B) 受体 调理性受体 Fc receptors Complement receptors 模式受体

  29. 抗原的加工处理Antigen processing

  30. (一) MHC-I类途径 内源性 Endogenous antigens CD8+ Tc cell

  31. (二) MHC-II类途径 外源性 Exogenous antigens CD4+ Th cell

More Related