FORESIGHT STUDY Future Trends and Challenges in Pathogenomics - PowerPoint PPT Presentation

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FORESIGHT STUDY Future Trends and Challenges in Pathogenomics

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  1. FORESIGHT STUDYFuture Trends and Challenges in Pathogenomics JUDITH SIMON & SVEN POMPE PROGRAMME GROUP MUT

  2. OBJECTIVES • Overview on future trends and challenges in research on human-pathogenic microorganisms (bacteria & fungi) • Developments in basic research • Diagnostics & therapy • Public health • Research co-operations • Technology transfer & market development

  3. STRUCTURE • Methods • Literature & internet research • Preliminary assessment • Expert survey • Results • Research foci • Methods, diagnostics & therapeutics • Challenges for research • Public health • Co-operations • Market development & technology transfer • Recommendations • Discussion

  4. METHODS • Triangulation: combination of literature and internet research with expert survey & interviews • "Triangulation [...] reduces the risk of systematic distortions inherent in the use of only one method.“ Maxwell 1998

  5. METHODS: Literature Research • Databases • PubMed • Medline • Important scientific journals • Keywords & combinations • pathogenomics, infectious disease, public health, bacteria, fungi, bioweapons, bioterrorism and/or human-pathogenic • Focus on reviews • Specialised articles on particular micro-organisms were excluded

  6. METHODS: Internet Research • Internet research on national & international • Surveys • Experts • Institutions • Networks

  7. METHODS: Preliminary Assessment • Addressee: • 62 members of the ERA-NET PathoGenoMicsfrom 17 countries • Questions • Contact partners and national institutions • National main foci in microbiological research • National newly emerging hot topics in pathogenomics • Existing foresight studies on pathogenomics or related subjects

  8. METHODS: Expert Survey • Development and application of questionnaires with questions on • Basic research • Future prospects in diagnostics & therapy • Strengths and weaknesses in research • Important cooperations and projects • Technology transfer & market development • Public health

  9. METHODS: Expert Survey A total of 329 experts was selected and contacted.

  10. Table 1: Reply & return rates METHODS: Expert Survey

  11. RESULTS: Research Foci

  12. RESULTS: Trends in Methodology • Improvement of conventional methods • Microscopy • Serology • Novel technologies • High-throughput analyses • Real time approaches • Bioinformatics • Omic‘s

  13. RESULTS: Trends in Omic`s • Systemic approach Proteomics Genomics Transcriptomics Metabolomics

  14. RESULTS: Trends in Omic`s • Understanding of: • Infection • Pathogenesis Genomics Transcriptomics Proteomics Metabolomics

  15. RESULTS: Trends in Diagnostics • Use of novel technologies • PCR • Sequence-based identification • Molecular strain typing • But tools need to be more ... • rapid • sensitive • specific • robust • affordable

  16. RESULTS: Challenges for Therapeutics • Extension of databases & discovery of molecular strategies In order to ... • enable comprehensive statistical and comparative analyses • standardise & validate diagnostics • find novel targets • develop new vaccines • innovate antibiotic intervention • individualise therapy

  17. RESULTS: Challenges for Research • Multidisciplinary research on • Ecology & environment • Population dynamics • Evolution & taxonomy • Epidemiology • Risk assessment

  18. RESULTS: Challenges for Research • Basic research on infection & pathogenesis • Analysis of host-pathogen-interaction • Identification of signaling pathways • Analysis of metabolic interactions • Identification of virulence factors • Target identification • ...

  19. „Infectious diseases account for [...] 25 % of global deaths (over 14 million deaths annually)“ (WHO 2000) RESULTS: Public Health - Risks • Major risks are • Multidrug resistance (cf. tuberculosis) • Nosocomial infections • Bioterrorism

  20. RESULTS: Public Health Measures • Surveillance systems • Action plans for emergencies • Vaccination strategies • Rapid and early diagnostics

  21. Table 2: Co-operations and global players (N=30) RESULTS: Co-operations What are the most important research partners for scientists in pathogenomics?

  22. Barriers High R&D costs Limited market size for vaccines and antibiotic products compared to the market for diseases of civilisation Opportunities Public-private partnerships Subcontracting with SME`s for preclinical studies Public funding for orphan drugs RESULTS: Market Development & Technology Transfer

  23. RECOMMENDATIONS 1. Establish a European surveillance system 2. Reduce the misuse of pesticides in agriculture and animal technology 3. Create a European Competence Center for epidemiological research and modelling 4. Create an R&D programme that is specifically tailored to support public-private partnerships 5. Create structures for early warning and rapid response to emergencies

  24. RECOMMENDATIONS 6. Develop comparative risk assessment strategies for setting national health priorities 7. Reconsider work-sharing between research institutes and universities 8. Foster cooperations between microbiological researchers and clinicians 9. Foster inclusion of ecological aspects into microbiology 10. Improve transparency about the function of different networks on pathogenomics 11. Conduct a study on industrial research objectives and economic interests

  25. THANK YOU VERY MUCH FOR YOUR ATTENTION! The complete report on FUTURE TRENDS AND CHALLENGES IN PATHOGENOMICS will soon be available at http://www.pathogenomics-era.net

  26. RECOMMENDATIONS 1. Establish a European surveillance system 2. Reduce the misuse of pesticides in agriculture and animal technology 3. Create a European Competence Center for epidemiological research and modelling 4. Create an R&D programme that is specifically tailored to support public-private partnerships 5. Create structures for early warning and rapid response to emergencies 6. Develop comparative risk assessment strategies for setting national health priorities 7. Reconsider work-sharing between research institutes and universities 8.Foster cooperations between microbiological researchers and clinicians 9. Foster inclusion of ecological aspects into microbiology 10. Improve transparency about the function of different networks on pathogenomics 11. Conduct a study on industrial research objectives and economic interests