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TRO

Explore the classification, structure, and therapeutic uses of sympathomimetic drugs that mimic the effects of the sympathetic nervous system. Learn about adrenergic agonist agents and their diverse applications in various medical conditions.

katherinehill
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TRO

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  1. SYMPATHETIC NERVOUS SYSTEM TRO DR. K.C.SWAIN PROF. & HEAD DEPT. OF PHARMACOLOGY

  2. SYMPATHOMIMETIC [ADRENERGIC AGONIST] AGENTS/DRUGS. • These drugs or agents when administered produce the effects which are mimic or similar to the effects produced as a result of activation of sympathetic nervous system.

  3. Most of these agents posses either an intact or partially substituted amino { NH2} groups in their chemical structures for which they are often called as sympathomimetic amines.

  4. AMPHETAMINE • TYRAMINE dihydroxybenzene agents having “OH” [HYDROXYL} GROUPS AT ADJACENT{ BOTH} 3RD & 4TH POSITIONS OF BENZENE RING . which do not posses “OH” GROUP AT BOTH ADJACENT POSITION OF BENZENE RING BUT ONLY AT ONE POSITION EITHER 3RD OR 4TH OR 5TH. • EPHEDRINE • METARAMINOL • DOPAMINE • MEPHENTERMINE ENDOGENEOUS SYNTHETIC • ADRENALINE • NOR-ADRENALINE • DOPAMINE • DOBUTAMINE • ISOPRENALINE • ETHYLNORADRENALINE • PRENALTEROL • ISOETHARINE

  5. CLASSIFICATION OF NON-CATECHOLAMINES. NASAL DECONGESTANT SELECTIVE α 1 AGONIST. SELECTIVE β2 AGONIST SELECTIVE α2 AGONIST NASAL DROPS : 1.XYLOMETAZOLINE-.05-1% 2.TETRAHYDOZOLINE- .05-1%. 3.OXYMETAZOLINE-.05-1%. 4.NAPHAZOLINE { NOT TO BE USED. PRIVINE.} 5.PHENYLEPHRINE 6.TUAMINOHEPTANE SULPHATE . 7.PROPYLHEXEDRINE NASAL INHALER{ 250 mg} ORAL ROUTE : 8.PSEUDOEPHEDRINE. 9.PHENYLEPHRINE 10.PHENYLPROPANOLAMINE. 1.SALBUTAMOL 2.TERBUTALINE 3.METAPROTERENOL 4.RITODRINE 5.FENOTEROL 6.QUINATERANOL 7.FORMOTEROL{ t1/2=12hrs.RAPID ACTION } 8.SALMETEROL{t½=12hrs. Slow action} 9.ARFORMOTEROL{R,R isomer of formoterol & twice more potent than formoterol ,long acting, given by nebulization] 10.BITOLTEROL 1.METHOXAMINE 2.PHENYLEPHRINE 3.MEPHENTERMINE 4.METARAMINOL 5.MIDODPINE 1.METHYLDOPA 2.CLONIDINE 3.APRACLONIDINE 4.GUANABENZ 5.TIZANIDINE{MUSCLE RELAXANT} 6.BRIMONIDINE { DECREASES I.O.P. }

  6. CARDIAC INOTROPICS 1.DOBUTAMINE 2.DOPAMINE. 3.ADRENALINE. 4.ISOPRENALINE. BRONCHODILATORS :1.ADRENALINE 2.ISOPRENALINE 3.EPHEDRINE 4.SELECTIVE β2—.AGONISTS. LOCAL VASOCONSTRICTORS : 1.ADRENALINE 2.PHENYLEPHRINE VASOPRESSOR AGENTS : 1.NOR-ADRENALINE 2.PHENYLEPHRINE 3.METARAMINOL 4.MEPHENTERMINE 5.METHOXAMINE 6.METHOXYPHENA MINE. Classification of sympathomimetc agents on the basis of therapeutics(I).

  7. Classification of sympathomimetic agents on the BASIS OF Therapeutics [ II] UTERINE RELAXANTS C.N.S. STIMULANTS ANOREXIANTS. NASAL DECONGESTANTS ANTIANAPHYLACTIC/ANTI ALLERGIC AGENTS. Adrenaline Ephedrine Ritodrine Salbutamol Isoxsuprine Fenfluramine Dextroamphetamine Phentermine sibutramine Amphetamine Ephedrine IN - I

  8. ROLE OF PRESYNAPTIC ALPHA-2 & BETA -2 ON HOMOTROPIC & HETROTROPIC RECEPTORS

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