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SYMPATHETIC NERVOUS SYSTEM. TRO. DR. K.C.SWAIN PROF. & HEAD DEPT. OF PHARMACOLOGY. SYMPATHOMIMETIC [ADRENERGIC AGONIST] AGENTS/DRUGS.

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  1. SYMPATHETIC NERVOUS SYSTEM TRO DR. K.C.SWAIN PROF. & HEAD DEPT. OF PHARMACOLOGY

  2. SYMPATHOMIMETIC [ADRENERGIC AGONIST] AGENTS/DRUGS. • These drugs or agents when administered produce the effects which are mimic or similar to the effects produced as a result of activation of sympathetic nervous system.

  3. Most of these agents posses either an intact or partially substituted amino { NH2} groups in their chemical structures for which they are often called as sympathomimetic amines.

  4. AMPHETAMINE • TYRAMINE dihydroxybenzene agents having “OH” [HYDROXYL} GROUPS AT ADJACENT{ BOTH} 3RD & 4TH POSITIONS OF BENZENE RING . which do not posses “OH” GROUP AT BOTH ADJACENT POSITION OF BENZENE RING BUT ONLY AT ONE POSITION EITHER 3RD OR 4TH OR 5TH. • EPHEDRINE • METARAMINOL • DOPAMINE • MEPHENTERMINE ENDOGENEOUS SYNTHETIC • ADRENALINE • NOR-ADRENALINE • DOPAMINE • DOBUTAMINE • ISOPRENALINE • ETHYLNORADRENALINE • PRENALTEROL • ISOETHARINE

  5. CLASSIFICATION OF NON-CATECHOLAMINES. NASAL DECONGESTANT SELECTIVE α 1 AGONIST. SELECTIVE β2 AGONIST SELECTIVE α2 AGONIST NASAL DROPS : 1.XYLOMETAZOLINE-.05-1% 2.TETRAHYDOZOLINE- .05-1%. 3.OXYMETAZOLINE-.05-1%. 4.NAPHAZOLINE { NOT TO BE USED. PRIVINE.} 5.PHENYLEPHRINE 6.TUAMINOHEPTANE SULPHATE . 7.PROPYLHEXEDRINE NASAL INHALER{ 250 mg} ORAL ROUTE : 8.PSEUDOEPHEDRINE. 9.PHENYLEPHRINE 10.PHENYLPROPANOLAMINE. 1.SALBUTAMOL 2.TERBUTALINE 3.METAPROTERENOL 4.RITODRINE 5.FENOTEROL 6.QUINATERANOL 7.FORMOTEROL{ t1/2=12hrs.RAPID ACTION } 8.SALMETEROL{t½=12hrs. Slow action} 9.ARFORMOTEROL{R,R isomer of formoterol & twice more potent than formoterol ,long acting, given by nebulization] 10.BITOLTEROL 1.METHOXAMINE 2.PHENYLEPHRINE 3.MEPHENTERMINE 4.METARAMINOL 5.MIDODPINE 1.METHYLDOPA 2.CLONIDINE 3.APRACLONIDINE 4.GUANABENZ 5.TIZANIDINE{MUSCLE RELAXANT} 6.BRIMONIDINE { DECREASES I.O.P. }

  6. CARDIAC INOTROPICS 1.DOBUTAMINE 2.DOPAMINE. 3.ADRENALINE. 4.ISOPRENALINE. BRONCHODILATORS :1.ADRENALINE 2.ISOPRENALINE 3.EPHEDRINE 4.SELECTIVE β2—.AGONISTS. LOCAL VASOCONSTRICTORS : 1.ADRENALINE 2.PHENYLEPHRINE VASOPRESSOR AGENTS : 1.NOR-ADRENALINE 2.PHENYLEPHRINE 3.METARAMINOL 4.MEPHENTERMINE 5.METHOXAMINE 6.METHOXYPHENA MINE. Classification of sympathomimetc agents on the basis of therapeutics(I).

  7. Classification of sympathomimetic agents on the BASIS OF Therapeutics [ II] UTERINE RELAXANTS C.N.S. STIMULANTS ANOREXIANTS. NASAL DECONGESTANTS ANTIANAPHYLACTIC/ANTI ALLERGIC AGENTS. Adrenaline Ephedrine Ritodrine Salbutamol Isoxsuprine Fenfluramine Dextroamphetamine Phentermine sibutramine Amphetamine Ephedrine IN - I

  8. ROLE OF PRESYNAPTIC ALPHA-2 & BETA -2 ON HOMOTROPIC & HETROTROPIC RECEPTORS

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