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Analysis of Gli3 and Pax6 Interactions in Whole Retina Development

This study investigates the roles of Gli3 and Pax6 gene modulation in the development of the whole retina, utilizing various measurement points (mm) to assess retinal structures. We performed statistical analyses comparing different developmental stages, noting significant differences (p < 0.05 and p < 0.001) related to ONL, INL, OPL, and IPL layers. The findings suggest complex interactions and regulatory mechanisms in retinal development, potentially influencing future research and therapeutic strategies for retinal disorders.

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Analysis of Gli3 and Pax6 Interactions in Whole Retina Development

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  1. ** * ** B ** ** ** ** ** * 210 190 mm 170 150 whole retina 130 wt wt wt wt wt Gli3+/- Gli3+/- Gli3+/- Gli3+/- Gli3+/- Pax6+/- Pax6+/- Pax6+/- Pax6+/- Pax6+/- Gli3+/-; Pax6+/- Gli3+/-; Pax6+/- Gli3+/-; Pax6+/- Gli3+/-; Pax6+/- Gli3+/-; Pax6+/- 65 50 60 45 mm 55 40 50 35 45 30 ONL INL 40 25 20 80 ** ** 18 70 mm 16 60 14 50 12 OPL IPL 10 40 A l r on C D E F ** * ** * ** * p = <0.05 ** p = <0.001

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