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Something we learn from textbook. White fat cell Store energy Monolocular( 单房的 ) Brown fat cell Dissipate energy [ high mitochondrial UCP1( uncoupling protein 1 ) ] Multilocular In small mammals, not in large mammals after infancy. Some new progress. “ brown conversion ”of white fat
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Something we learn from textbook • White fat cell • Store energy • Monolocular(单房的) • Brown fat cell • Dissipate energy [high mitochondrial UCP1(uncoupling protein 1)] • Multilocular • In small mammals, not in large mammals after infancy
Some new progress • “brown conversion”of white fat • Brown fat in adult humans • UCP1+ • Particularly in supraclavicular and neck region cold or cAMP • White fat tissue • UCP1﹣ • UCP1+ • brown fat cell • UCP1+ • Derived from myf-5 lineage
Questions • Beige fat cell is a distinct cell type or derived from white fat cells ? • The brown fat tissue in adult human is classical brown fat or beige fat ?
第一PPT模板网 WAT: white adipose tissue BAT: brown adipose tissue Lecturer: Cao Lijie
Beige adipocyte in white fat Beige fat cell readily detectable in Inguinal subcutaneous fat depot • Multilocular • UCP1 between WAT and BAT BAT Inguinal subcutaneous fat depot Epididymal WAT Brown fat cell-enriched protein
Beige adipocyte in white fat Ing Immortalization(无限增殖) … … cell lines differentiate … … beige fat cell White fat cell Beige fat cell is derived from a subset of precursor cells within white fat.
characteristics of Beige cells (By cAMP) Brown fat-- enriched protein
highlights “Brown” fat in human adults is composed of beige adipocytes subQ WAT White adipogenic cells Beige adipogenic cells Sympathetic stimulation Beige adipocyte