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Decursin Inhibits NF-kB Activation in THP-1 Cells Stimulated by LPS

This research explores how decursin impacts the activation of NF-kB in THP-1 cells when stimulated with lipopolysaccharide (LPS). THP-1 cells were pretreated with decursin for 2 hours before exposure to LPS (1 mg/ml). Immunofluorescence assays were used to assess the subcellular localization of NF-кB p50 after treatment at various time points. The findings indicate that decursin effectively blocks NF-kB activation, providing insights into its anti-inflammatory potential.

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Decursin Inhibits NF-kB Activation in THP-1 Cells Stimulated by LPS

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  1. Data supplement 4. Decursin blocks activation of NF-kB A LPS (1 mg/ml) Decursin (mM) - + + + + 0 0 10 25 50 B - 30 0 30 60 - + - + + 0 0 25 25 25 Time (min)) LPS (1 mg/ml) Decursin (mM) Decursin blocks activation of NF-kB. A, THP-1 cells were pretreated with decursin for 2 hrs and stimulated with 1 mg/ml LPS. Thirty minutes after the activation, subcellular location of p50 was tested using immunofluorescence assay. B, THP-1 cells were pretreated with decursin for 2 hrs and stimulated with 1 mg/ml LPS. The subcellular location of p50 was tested after indicated times.

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