Neuro-Psychiatric Comorbidity among Psoriatic Adolescents
This study investigates the neuro-psychiatric comorbidity in adolescents aged 16 to 18 with psoriasis, utilizing a population-based cross-sectional design based on military medical records. Findings reveal potential associations between moderate to severe psoriasis and psychological issues, including anxiety and headaches. The analysis highlights the need for clinicians to recognize the collateral impacts of psoriasis in adolescents, particularly those with more severe forms of the condition. The study underscores the importance of mental health assessments in managing psoriasis among youth.
Neuro-Psychiatric Comorbidity among Psoriatic Adolescents
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Presentation Transcript
Neuro-Psychiatric Comorbidity among Psoriatic Adolescents EranGalili, Aviv Barzilai, RonyShreberk-Hassidim, IlanMerdler, TommCaspi, NadavAstman Journal reference: 10.1111/bjd.16031
Introduction What’s already known? • Adultpsoriasis is a risk factor for psychiatric and neurological diseases • Few studies among children, comprising of subjects of mixed age groups (younger than 18 years), have linked psoriasis to anxiety, depression and social disabilities
Methods • Design: A population based cross-sectional study • Database: Army recruits’ medical records • Inclusion criteria: Age 16 to 18 years • Comparisons were made by multivariate analysis adjusted for: • Age, Gender, Country of origin, BMI, Socio-economic status and IQ score • Psoriasis severity definition: • Mild: with limited skin involvement, using topical treatment only • Moderate to severe: with extensive skin area involvement, or treated with phototherapy or systemic therapy
Methods: Assessed Comorbidity CNS, central nervous system; *Consists of: multiple sclerosis, neurodegenerative disease and cerebrovascular accident
Results: Characteristics of study participants * On a scale of 1 (lowest) to 10 (highest)
Results: Comparison of neuro-psychiatric comorbidity between psoriatic and healthy adolescents NS, non-significant; ᵃ Calculated for a subgroup of patients (Psoriasis N=1135, Controls N=265023); **pvalue < 0.01, ***pvalue < 0.001
Results: Influence of psoriasis severity compared to controls ᵃ Calculated for a subgroup of patients (Mild psoriasis N=669, moderate to severe psoriasis N=466 and controls N=265023), univariate analysis; **p value< 0.01, ***p value< 0.001
Discussion What does this study add? • Adolescent psoriasis was found to be associated with migraine and non-migraine headaches, as well as psychological symptoms, including anxiety and impaired social adjustment skills • Neuro-Psychiatric comorbidity was found to be related only to moderate to severe psoriasis
Conclusions • Clinicians should be aware of the collateral impact of psoriasis, especially upon adolescents with moderate to severe disease
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