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Effects of GW3965 on CXCL10 Production in Poly I:C Stimulated BEAS-2B Cells

This study investigates the impact of GW3965 on CXCL10 production from poly I:C stimulated BEAS-2B cells. Immunocytochemical analysis confirmed the expression of LXRα and LXRβ in BEAS-2B cells. Following treatment with either vehicle (DMSO), GW3965 at concentrations of 1 µM or 10 µM, or dexamethasone (1 µM) prior to stimulation with poly I:C, the culture supernatants were analyzed for CXCL10 levels. Results demonstrated a significant reduction in CXCL10 production with GW3965 treatment compared to vehicle control (p < 0.05).

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Effects of GW3965 on CXCL10 Production in Poly I:C Stimulated BEAS-2B Cells

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  1. (A) (B) • Additional File 10 (C) (D) (E) The effect of GW3965 on the production of CXCL10 from poly I:C stimulated BEAS-2Bs. Immunocytochemical staining confirmed the presence of LXRα (A) and LXRβ (B) in BEAS-2Bs. Omission of the primary antibodies displayed no immunoreactivity for LXRα (C) and LXRβ (D). (E) BEAS-2Bs (n=3) were pre-treated with vehicle (DMSO 0.05%) (white bars), GW3965 (1 µM or 10 µM) (light grey bars), or dexamethasone (1 µM) (dark grey bars) for 1 h prior to stimulation with poly I:C (10 µg/ml) for 24 h. Culture supernatants were analysed for CXCL10. Data shown are mean ± SEM where * = significant reduction of CXCL10 below vehicle control (p<0.05).

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