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This presentation showcases the cutting-edge research and innovations led by Dr. Duncan Maitland at Texas A&M University's Biomedical Engineering Department. Focusing on stroke and aneurysm treatments, the presentation discusses historical surgeries like surgical clipping and modern alternatives such as detachable coil embolization and SMP foam technology. Highlighting statistics on stroke prevalence and treatment costs, the talk emphasizes the lab's commitment to developing biocompatible devices that enhance patient outcomes. It underscores the importance of improving treatment methods while acknowledging contributions from students and collaborators.
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Biomedical Device Laboratory Dr. Duncan Maitland Associate Professor – Department of Biomedical Engineering Texas A&M University Mary Biediger John Marshall High School Northside Independent School District – San Antonio, Texas
Facts about Stroke • 750,000 cases per year • 150,000 deaths per year (3rd leading cause of death) • 30,000 hemorrhagic strokes (treatable) • Leading cause of disability • $40 billion spent on treatment and rehabilitation annually
Historical Treatment (since 1937) • Surgical Clipping – via craniotomy Still used today
If it’s working, why change it? • Surgery on any one area may cause problems with speech, memory, muscle weakness, balance, vision, coordination, and other functions. • Blood clot or bleeding in the brain • Seizures • Stroke • Coma • Infection in the brain, in the wound, or in the skull • Brain swelling Source: http://health.nytimes.com/health/guides/surgery/brain-surgery/overview.html
Timelines • Hospitalization – 5 to 7 days • Recovery time before returning to work – 6 to 12 weeks Source: http://www.umm.edu/news/releases/brain_aneurysm.htm
Alternative Treatment (since 1991) Detachable coil embolization -Can reach previously inoperable aneurysms
Risks • Catheter-related risks: Intra-arterial catheterization involves a risk of bleeding, infection and arterial damage. • Surgical risks: As with any invasive procedure, there is a slight risk of death or illness. • Approximately 7% of cases require additional treatment or surgery. Source: http://www.crrnc.com/dce.php#9
Additional Complications • Surgery time (varies with number of coils being implanted) • Doctors not happy • Patients not happy • Customers not happy – product less likely to sell • Clots forming in the blood stream • Problems downstream
Timelines • Hospitalization – 2 days • Recovery time before returning to work – about a week Source: http://www.umm.edu/news/releases/brain_aneurysm.htm
Cutting Edge Treatment • SMP Foam – made to fill aneurysm
Cutting Edge Treatment • Crimped to a cylindrical shape to be fed through a micro-catheter and actuated at the site.
Why do it? • Catheter and Anesthesia • Foam is more biocompatible • Healing time significantly reduced *This is one aspect of the work going on in the lab. It is nearly ready for animal trials, not yet used in humans.
Another treatment (currently in use) - Metal Stent Reinforce the weak artery wall Encourage normal blood flow Reopen partially blocked passages
Angioplasty vs. Stent Source: http://www.heartsite.com/html/stent.html
Stent use for aneurysm treatment • In combination with coiling • For “wide-neck” aneurysm. Source: http://www.muschealth.com/bin/h/a/stent%20bridging%20aneurysm%20neck%20to%20asisst%20coiling.jpg
In the lab • SMP plastic tube
Why do this? • Can you tell me
What I will do • Use an MRI from a current patient
What I will do • Make a model using 3D printer
What I will do • Make a negative model
What I will do • Create a SMP plastic stent to treat the aneurysm and test it in the model.
Summary • Focus of the lab: • Design devices to treat aneurysms, fistulas, and stroke • Improve treatment options from what is currently used in practice • Use Shape Memory Polymers to create devices that will be more readily accepted by the human organism
Acknowledgements • TAMU E3 program • NSF, NPI, and TWC • Dr. Duncan Maitland, PhD.
Acknowledgements • John Horn – Graduate student who is graciously donating his time to teaching me about the work in the lab. • All of the graduate students in the biomedical lab who gleefully answer my queries about their various projects.