html5-img
1 / 7

Genetic epidemiology

Genetic epidemiology. Claire Infante-Rivard MD, PhD James McGill Professor. In the news: is it accurate information?. The heterogeneous A/G genotype was present in 29.5% of patients with VWF and 0.3% of the controls ( P <0.001), the researchers reported online in Clinical Epigenetics .

kesler
Télécharger la présentation

Genetic epidemiology

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Genetic epidemiology Claire Infante-Rivard MD, PhD James McGill Professor

  2. In the news: is it accurate information? • The heterogeneous A/G genotype was present in 29.5% of patients with VWF and 0.3% of the controls (P<0.001), the researchers reported online in Clinical Epigenetics. • "We therefore claim [that] genotype to be a risk factor for VWF, and that it may be used as a biological marker to facilitate the identification of risk populations who are being considered for exposure to potentially hazardous handheld vibrating machinery," they wrote. • "This may prevent thousands of employees from experiencing physical pain and disability, in addition to long-lasting administrative fights for VWF compensation, which frequently end unsettled and in great frustration • Voelter-Mahlknecht S, et al "Sirtuin 1 single nucleotide polymorphism (A2191G) is a diagnostic marker for vibration-induced white finger disease" Clin Epigenetics 2012.

  3. Areas of study • Small-for-gestational age babies • Lifestyle, biological, and genetic factors • Infante-Rivard C et al. New Engl J Med 2002; 347:19-24 • Infante-Rivard C. Am J Epidemiol 2010;171:999-1006. • Childhood leukemia • Environmental and genetic risk factors, lifestyle of parents; international consortium with the goal of pooling data • Infante-Rivard C et al. Am J Epidemiol 2007;165:1248-54 • Childhood brain tumors • Environmental and eventually genetic risk factors: international consortium in development • Roncarolo F, Infante-Rivard C. Cancer Causes and Control 2012;23:617-23. • Childhood asthma • Environmental and genetic risk factors • Infante-Rivard C et al. Am J Epidemiol 1999;150:528-31.

  4. More • Interest in family trios • How to use genetic data from both families and case-control together in the analysis • Infante-Rivard C, Mirea L, Bull SB Am J Epidemiol 2009;170:657-64 • The importance of transmission ratio distortion (transmission of alleles in trios) in control trios when analyzing case trios • Huang (PhD candidate), Labbe, Infante-Rivard

More Related