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Mucous Membrane Pemphigoid: Symptoms and Diagnosis

Mucous Membrane Pemphigoid (MMP) is a chronic blistering disease affecting oral and ocular mucous membranes, with unknown causes. Ig and complement deposition along the basement membrane are characteristic. Learn about symptoms and diagnostic methods.

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Mucous Membrane Pemphigoid: Symptoms and Diagnosis

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  1. Pemphigoid:

  2. Mucous membrane pemphigoid (MMP) is chronic blistering or vesiculobullous disease that affects predominately oral and ocular mucous membranes. an autoimmune disease (autoimmune reaction to basement membrane protein ) with an unknown stimulus. Deposition of Ig and complement component along the basement membrane zone ( on DIF testing ) are characteristic.

  3. When it is affects gingiva called desquamative gingivitis.

  4. Histopathology: MMP is a subepithelialcleftingdisorder and there is no acantholysis. In early stages few lymphocytes are seen, but with time the infiltrate becomes more dense and mixed.

  5. Direct immunofluorescence studies a continuous linear band of immunoreactantsat the basement membrane zone in nearly 90% of affected patients IgG and C3, although IgA and IgM Indirect immunofluorescence is positive in only 5% of these patients

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