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Regulation of Ca ++ Homeostasis in the Hearts of Female Rats

Regulation of Ca ++ Homeostasis in the Hearts of Female Rats. Sarah-Ne ïel Barama October 19 th 2006 Supervisor: Dr. Chalifour (LDI). Background & Hypothesis. Relationship b/w ♥ & hormones Ca ++ Homeostasis proteins ( NCX1, SERCA2a, PLB, CSQ, CRT…) Contract = Ca ++ → cytosol

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Regulation of Ca ++ Homeostasis in the Hearts of Female Rats

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  1. Regulation of Ca++ Homeostasis in the Hearts of Female Rats Sarah-Neïel Barama October 19th 2006 Supervisor: Dr. Chalifour (LDI)

  2. Background & Hypothesis • Relationship b/w ♥ & hormones • Ca++ Homeostasis proteins (NCX1, SERCA2a, PLB, CSQ, CRT…) • Contract = Ca++ → cytosol • Relax = Ca++ → SR & ECM • Acute Stress: exercise • Oxidative stress : Doxorubicin ± Dexrazoxane Hyp: Expression of Ca++ regulating proteins is . Hormone-dep and is correlated to ♥ fct

  3. Method • Intact VS Ovariectomy • Sedentary or Exercised • PBS or DOX or DOX:DEX • ♥ Extraction & Homogenisation in RIPA • Western Blot, densitometer

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