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Understanding Sphingolipid Metabolism: A Comprehensive Overview

Explore the intricate pathways and functions of sphingolipid metabolism in cells, from squalene epoxide to phytoceramide synthesis. Learn about key enzymes and metabolites involved in this crucial cellular process.

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Understanding Sphingolipid Metabolism: A Comprehensive Overview

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Presentation Transcript

  1. ERG1 squalene epoxide ERG7 ERG11 dimethyl zymosterol ERG25 ERG24 squalene lanosterol O2 O2 O2 ERG27 ERG6 ERG2 ERG26 ERG25 ERG26 zymosterol fecosterol episterol O2 ERG3 ERG5 ERG4 ergostatrienol ergosterol A O2 O2 palmityl-CoA L-serine LCB1 LCB2 sphinganine d18:0 LCB3 O2 O2 DES1 O2 SLD1 SUR2 1-P-phytosphinganine phytosphinganine t18:0 4-sphingenine d18:1Δ4 8-sphingenine d18:1Δ8 LCB4 LCB5 SLD1 DES1 LAC1 LAG1 YPC1 O2 O2 4,8-sphingadienine d18:2Δ4,8 phytoceramide O2 SCS7 Sphingolipid C9-methyltransferase α-hydroxy phytoceramide GlcCers AUR1 inositol-P-ceramide CSH1 B MIPC

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