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Microbial Metabolism

LECTURE 10:. Microbial Metabolism. Microbiology and Virology; 3 Credit hours Atta- ur - Rahman School of Applied Biosciences (ASAB) National University of Sciences and Technology (NUST). ATP. Interesting Fact.

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Microbial Metabolism

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  1. LECTURE 10: Microbial Metabolism Microbiology and Virology; 3 Credit hours Atta-ur-Rahman School of Applied Biosciences (ASAB) National University of Sciences and Technology (NUST)

  2. ATP

  3. Interesting Fact • ATP is continuously recycled in organisms: the human body, which on average contains only 250 grams of ATP,turns over its own body weight equivalent in ATP each day. • The collective metabolic capacities of bacteria allow them to metabolize virtually every organic compound on this planet.

  4. Substrate level phosphorylation

  5. Sugar Metabolic Network in Bacteria

  6. Amphibolic Pathway

  7. THE BREAKDOWN OF GLUCOSE TO PYRUVATE • Microorganisms employ several metabolic pathways to catabolize glucose and other sugars • The Embden Meyerhof pathway, • The pentose phosphate pathway, and • The EntnerDoudoroff pathway • These three pathways are collectively called as glycolytic pathways or as glycolysis

  8. Stage 1 Stage 2 Glycolytic Pathway The Embden Meyerhof pathway

  9. Stage 1

  10. Stage 2 Triose phosphate isomerase Glyceraldehyde 3 phosphate dehydrogenase Phosphoglycerate kinase Phosphoglycerate mutase Enolase Pyruvate Kinase

  11. The Pentose Phosphate Pathway

  12. The Pentose Phosphate Pathway Importance in Biosynthesis • NADPH from the pentose phosphate pathway serves as a source of electrons for the reduction of molecules during biosynthesis • Two important precursor metabolites: • erythrose 4-phosphate, which is used to synthesize aromatic amino acids and vitamin B6 (pyridoxal) • and ribose 5-phosphate which is a major component of nucleic acids. • Hexose sugars needed for peptidoglycan synthesis

  13. The EntnerDoudoroffPathway

  14. KDPG aldolase This pathway yields one ATP, one NADPH, and one NADH per glucose metabolized

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