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TRPV1
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MOLECULAR BASIS & REGULATION OF TRPV1 ACTIVITY. Bradykinin B 2 PAR2 P 2 Y. PGE 2. EP1 EP2. NGF. cAMP. AEA NADA. TrkA. 12-( S )-HPETE 15-( S )-HETE LTB 4. PKA. +. PKC. +. α. βγ. +. +. +. +. IP3. ?. +. DAG. Ca 2+. AC. Ca 2+. Ca 2+. PIP2. C. PLC. P. N. Gs.
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TRPV1
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Presentation Transcript
MOLECULAR BASIS & REGULATION OF TRPV1 ACTIVITY Bradykinin B2 PAR2 P2Y PGE2 EP1 EP2 NGF cAMP AEA NADA • TrkA 12-(S)-HPETE 15-(S)-HETE LTB4 PKA + PKC + α βγ + + + + IP3 ? + DAG Ca2+ AC Ca2+ Ca2+ PIP2 C PLC P N Gs Ethanol TRPV1 Low pH (5-6) Temperature (>43ºC)
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