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  1. Beta-1,3/1,6-Glucan Presented by Mikuni Immune Exclusive Importer for Sophy, Japan

  2. Mikuni Immune • The key to good health is a healthy immune system however; your immune system can be compromised by germs, pollution, and stress. Clinical studies have shown that Mikuni Immune Beta-1,3/1,6-Glucan helps support your immune system. Our unique harvesting process results in a product of exceptionally high quality and purity.

  3. Laboratory studies on Mikuni Beta Glucan show the following health effects: • Support healthy lymphocyte levels * • Produces cytokines which is essential to proper immune function* • Support regulation of receptors important to healthy immune response* • Supports the body’s ability to fight free radicals* • Supports activation of natural killer cells*

  4. Mikuni Beta Glucan culture fluid may have a healthful effect on the following: •   May mitigate menopausal discomfort • Supports the systems that neutralize free radicals • Helps relieve occasional constipation or irregularity •   Supports healthy immune resistance •   Supports healthy hair growth • Supports physical strength

  5. What is Beta Glucan? Molecular Structure of Beta-1,3/1,6-Glucan A Polysaccharide (sugar) formed from linking many glucose molecules together. The molecular structure (linkage) of Beta Glucan is a combination of its main and side chains. The structure, 1,3/1,6, whereby 1,3 is the main chain and 1,6 is the side chain, is the most effective immune booster.

  6. How Does it Work? • Mikuni Beta Glucan safely supports your immune system and your body’s natural defenses.* • Studies in vitro and in animals support the immune responses seen in humans.* • Our product is completely pure; harvested during the natural growth of yeast while the yeast cells are in the process of reproducing. • Contains only the 1,3/1,6 linkage, that has been shown through clinical trials to be the most bioactive immune stimulator.

  7. Why it is Superior? • Made with ingredients from U.S. patent No. 6,956,120 B2 • Uniformity of size of particles • It has a Beta-1,3/1,6 linkage to support the immune system that makes it unlike the Beta-1,3/1,4 linkages found in oats or oat fibers • Has been rated by the FDA as GRAS (Generally Recognized As Safe)

  8. Superior Immune Support Mikuni ImmuneBeta-1,3/1,6-GlucanDerived from Black Yeast (Aureobasidium pullulans){NOT BAKERS YEAST} • A PROMISING PRODUCT DEVELOPED OVER 30 YEARS SUPPORTED BY NUMEROUS CLINICAL STUDIES BY LEADING JAPANESE PHYSICIANS.

  9. History of Beta-1,3/1,6-Glucan Beta Glucan research began in 1941 with the discovery of the immune-activating substance called Zymosan which is an immunoactive substance from yeast walls. In the 1960’s an apparent explanation on this question was given when a research group discovered that the active component of Zymosan was Beta-1,3-1,6-Glucan.

  10. History of Beta-1,3/1,6-Glucan(cont.) Over 30 years ago, inventors NobunaoIkawaki, NobouruFujii, & Takashi Onaka traveled to Norway to visit a fishery where the fish were not receiving any antibiotics or additives, yet remained very healthy. The inventors learned that the fish were being fed glucan. As the result of their discovery, they received a grant from the Japanese Government to research this in state owned hospitals.

  11. History of Beta-1,3/1,6-Glucan(cont.) In 1996, SOPHY B-glucan under the trade name Aureobasidium (a scientific name for black yeast) Cultured Solution became the first B-glucan to be approved by Japan’s Ministry of Health, Labor & Welfare as an existing food additive (also called a ‘natural food additive’), thus gaining official recognition as being safe for use as an ingredient in food. SOPHY B-glucan has transcended the boundaries of conventional health food & now is used to provide added functionality as an additive in ordinary food & cuisine.

  12. About Us The primary goal of Mikuni Immune is to contribute to society globally by offering the highest quality, pure Beta-1,3 /1,6-Glucan available derived from a natural product that is effective and safe for people, animals and the environment. Mikuni Beta-1,3 /1,6-Glucan is derived from the black yeast, Aureobasidiumpullulans, cultivated in Japan and harvested under sterile conditions. Produced by SophyCorporation, Japan Exclusively Imported By Mikuni Immune

  13. More about SOPHY B-Glucan • Is being used by Shiseido – a top of the line international cosmetics company – in products for anti-aging & sun protection. • For Pet Food and supplements • Contains no proteins, fat, fillers, or contaminates that could be toxic

  14. The characteristics of SOPHY B-glucan as an ingredient is not limited to food products: • Live stock farming • Pharmaceutical or medical products or treatments. • Nutritional products • In diagnostic products & methods

  15. Clinical Studies: (SophyBeta-1,3/1,6-Glucan) Japan Date: Jan 15, 2011 The 14th Annual Assembly of Japan Society of Metabolism and Clinical Nutrition. Presented by Sasaoka et al. Patients were given Sophy beta glucan. 18 patients took 15mL 3 times per day for 3 months. Blood was drawn prior to administration of beta glucan. Natural Killer Cell activity was measured and examined each time. NK cell activity was increased in 1 month(126.4±13.76.%), 2 months (129.7±10.24%), and 3 months (116.2±8.36%) time period. Beta glucan appears to induce cell immunity and thereby may be beneficial in helping to support immune system function.

  16. Clinical Studies: (Sophy Beta-1,3/1,6-Glucan) Japan (cont.) Date : Jan 29, 2009 The 24th Assembly of Japanese Society for Parenteral and Enteral Nutrition. Presented by Yano et al. Immunostimulatory effects of Sophy beta glucan in humans. Study on 29 healthy individuals. Group 45ml: 11 people took Sophy beta glucan 45ml a day (15ml each, 3 times a day) for a month. NK activity was measured by 51Cr- release assay. Group 5ml: 9 people took 5 ml a day Group 30 ml: 9 people took 30 ml a day In Group 45 ml, 90.9 % (10/11) of the people had an increase of NK activity. The NK activity increased from 100% (before intake) to 122.5 ±8.48% (p=0.0213) and it was statistically significant. After stopping taking, NK activity decreased to the original level in 62.5 % of the people. The data were statistically significant (p=0.0002, p=0.0402). Sophy beta glucan was proved to increase immunostimulatory effects in human. The effect depends on the duration of intake.

  17. References: Ikewaki N, Fujii N, Onaka T, Ikewaki S, Inoko H. Immunological actions of Sophy beta-glucan (beta-1,3-1,6 glucan), currently available commercially as a health food supplement. MicrobiolImmunol.  2007;51(9):861-873. Ikewaki N, Fujii N, Onaka T. et al.  Immunologic responses of human peripheral blood mononuclear cells (PBMCs) derived from healthy donors cultured with β-1,3-D/1,6 glucan produced by Aureobasidiumpullulans.  J of Kyushu University of Health and Welfare. 2005;6:193-198. Ikewaki N, Fujii N, Onaka T, Inuko H.  Unique immunological actions of a new β-1,3-D/1,6 glucan (Sophy β-glucan) produced by Aureobasidiumpullulans strain AFO-202.  J of ClinImmun 2000;20:4:317-324. Yatawara L, Wickramasinghe S, Nagataki M, Takamoto M, Nomura H, Ikeue Y, Watanabe Y, Agatsuma T. Aureobasidium-derived soluble branched (1,3-1,6) beta-glucan (Sophy beta-glucan) enhances natural killer activity in Leishmaniaamazonensis-infected mice. Korean J Parasitol. 2009 Dec;47(4):345-51. The adjuvant effect of Sophy β-glucan to the antibody response in poultry immunized by the avian influenza A H5N1 and H5N2 vaccines. Le T, Le T, Doan TH, Quyen D, Le KX, Pham V, Nagataki M, Nomura H, Ikeue Y,Watanabe Y, Agatsuma T. J MicrobiolBiotechnol. 2011 Apr;21(4):405-11. Effects of Sophy β-glucan on growth performance, carcass traits, meatcomposition, and immunological responses of Peking ducks. Tang XY, Gao JS, Yuan F, Zhang WX, Shao YJ, Sakurai F, Li ZD. Poult Sci. 2011 Apr;90(4):737-45. Effect of Sophy β-glucan on immunity and growth performance in broiler chicken. Rajapakse JR, Buddhika MD, Nagataki M, Nomura H, Watanabe Y, Ikeue Y, Agatsuma T.J Vet Med Sci. 2010 Dec;72(12):1629-32. Epub 2010 Jul 21.

  18. Personal Testimonials I'm in my 40's and due to my family history, I was concerned about maintaining my health. I took Mikuni Beta Glucan 500mg daily for six months, and along with diet changes and regular exercise I am confident that I can stay healthy. My doctor is amazed!  I continue to take 250mg of Mikuni Beta Glucan daily to compliment my healthy lifestyle changes.   Toby Scott, San Diego CA After recovering from a respiratory infection I wanted to do something to keep my immune system strong.  Along with limiting my exposure to allergens by getting dust mite covers for my bedding and limiting exposure to second hand smoking, I began taking 400mg of Mikuni Beta Glucan per day mixed in my green tea. I would recommend it to anyone to help support their immune system.   Dennis Burnham, Poway CA

  19. Product of 250mg x 30 capsules Label Serving Size: Take 1 capsule, 250 mg daily To activate your immune system, start with 2 capsules per day (500mg).  Take one in the AM and one in the PM for two weeks Contains no: Dairy, Lactose, Egg, Corn, Soy, Wheat, Gluten, Starch, Preservatives, or Artificial colors Laboratory tested and Quality Guaranteed.