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Immunity to infectious agents

Immunity to infectious agents. Immunity to extracellular bacteria. Disease is caused by two mechanisms: First ,inflammation Second,toxins ( endotoxins,exotoxins ). Innate immunity. Complement activation Phagocytosis Inflammatory response. Adaptive immunity to extracellular bacteria.

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Immunity to infectious agents

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  1. Immunity to infectious agents

  2. Immunity to extracellular bacteria • Disease is caused by two mechanisms: • First ,inflammation • Second,toxins(endotoxins,exotoxins)

  3. Innate immunity • Complement activation • Phagocytosis • Inflammatory response

  4. Adaptive immunity to extracellular bacteria • Antibodies a)Neutralization b)Opsonisation c)Complement activation Protein antigens of ex. Bacteria Activate Ths activation of macrophages and neutrophils Local Inflammation stimulate antibody production

  5. Injurious effects of immune response • Inflammation • Septic shock (circulatory collapse and DIC) • Microbial component macrophages cytokines(TNF,IL-1,IL-6) • Superantigens • Rheumatic fever • Nephritis

  6. Immunity to intracellular bacteria • Innate immunity Phagocytes and NK cells • DC and Macroph. IL-12 ,IL-15 Nkcells activation IFN- macrophage activation

  7. Adaptive immunity • T CD4 • T CD8

  8. Immunity to viruses • Innate immunity • Adaptive immunity • Antibodies • CTL

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