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Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells. Osteoscoop - Issue N°262 – November 2012. IGF-1 release. Osteoblasts. Osteoclasts. Bone resorption. Bone formation. IGF-1. Mesenchymal stem cell. Osteoblast differentiation. Preosteoblast.

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Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

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  1. Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells Osteoscoop - Issue N°262 – November 2012

  2. IGF-1 release Osteoblasts Osteoclasts Bone resorption Bone formation IGF-1

  3. Mesenchymal stem cell Osteoblast differentiation Preosteoblast + mTOR Igf1r IGF-1 release Osteoblasts Osteoclasts Bone resorption Bone formation IGF-1

  4. Mesenchymal stem cell Osteoblast differentiation Preosteoblast + mTOR Igf1r IGF-1 release Osteoblasts Osteoclasts Bone resorption Bone formation IGF-1 Young rat Low bone matrix IGF-1 Low bone formation IGF-1 Aged rat

  5. Mesenchymal stem cell Osteoblast differentiation Preosteoblast + mTOR Igf1r IGF-1 release Osteoblasts Osteoclasts Bone resorption Bone formation IGF-1 Young rat Low bone matrix IGF-1 Low bone formation Higher bone matrix IGF-1 Higher bone formation IGF-1 + IGFBP3 IGF-1 IGF-1 Aged rat Aged rat

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