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This lecture explores the critical role of dopamine in the brain's chemical synapses. It delves into how dopamine influences movement, thought processes, and emotional regulation, particularly through the ventral tegmental area (VTA) and nucleus accumbens, key pleasure centers. Furthermore, it addresses the pathology related to dopamine, highlighting the destruction of dopaminergic neurons in the substantia nigra as a fundamental cause of Parkinson's disease and the elevated levels of D2 receptors found in patients with schizophrenia.
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Neurotransmitters Lec 6
Dopamine / SubstantiaNigra • Physiological Role; controlling movement, thought processes, emotions, and the pleasure centers of the brain (Ventral tegmental area “VTA” & Nucleus accumbens). • Pathology; Destruction of the dopaminergic neurons in the substantianigra is the basic cause of Parkinson's disease. • Schizophrenic patients indicate elevated level of D2 receptors