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Path Jeopardy

Path Jeopardy. Cellular Responses. Topic 1: 1 point. What are the four components of repair?. Angiogenesis Migration and proliferation of fibroblasts Deposition of ECM Remodeling. Topic 1: 2 points. By 3-5 days of tissue repair, what specialized tissue appears?. Granulation Tissue.

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Path Jeopardy

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  1. Path Jeopardy Cellular Responses

  2. Topic 1: 1 point • What are the four components of repair? • Angiogenesis • Migration and proliferation of fibroblasts • Deposition of ECM • Remodeling

  3. Topic 1: 2 points • By 3-5 days of tissue repair, what specialized tissue appears? Granulation Tissue

  4. Topic 1: 3 points • What are the two major factors that induce angiogenesis? • bFGF (basic fibroblast growth factor) • VEGF (vascular endothelial growth factor)

  5. Topic 1: 4 points • What are the three phases of cutaneous wound healing? Inflammation Proliferation Maturation

  6. Topic 1: 5 points This is the simplest type of cutaneous wound repair; healing of a clean, uninfected surgical incision that is then approximated by surgical sutures Healing by primary intention; primary union

  7. Topic 2: 1 point This type of cell replaces neutrophils around 48-96 hours during tissue repair Macrophage

  8. Topic 2: 2 points This is the most important fibrogenic agent in cell proliferation TGF-B

  9. Topic 2: 3 points What are the factors that influence wound healing? Nutrition Metabolic status Circulatory status Hormones Infection Mechanical factors Foreign bodies Size, location, and type of wound

  10. Topic 2: 4 points Excessive formation of collagen that develops following thermal or traumatic injury can give rise to this Hypertrophic Scar

  11. Topic 2: 5 points The signaling mechanism by which the cells respond to the signaling molecules that they themselves secrete Autocrine Signaling

  12. Topic 3: 1 point This signaling mechanism occurs when one cell type produces the ligand and then acts on adjacent target cells that express the appropriate receptor Paracrine signaling

  13. Topic 3: 2 points This signaling mechanism occurs when hormones synthesized by cells of endocrine organs act on target cells distant from their site of synthesis Endocrine signaling

  14. Topic 3: 3 points These receptors transmit signals into the cell through trimeric GTP-binding proteins, contain seven transmembraneα-helices, and constitute the largest family of plasma membrane receptors G-Protein Coupled Receptors

  15. Topic 3: 4 points This type of growth occurs by enlargement of the lobes of the liver that remain after the operation Compensatory growth or compensatory hyperplasia

  16. Topic 3: 5 points This is the most abundant glycoprotein in the basement membrane and it contains binding domains for both ECM and cell surface receptors Laminin

  17. Topic 4: 1 point This substance provides resilience and lubrication to connective tissue (notably for the cartilage in joints) and its concentration increases in inflammatory diseases Hyaluronan

  18. Topic 4: 2 points These are represented by pale platelet and fibrin deposits alternating with darker red cell-rich layers. It signifies that a thrombus has formed in flowing blood Lines of Zahn

  19. Topic 4: 3 points These are thrombi on heart valves resulting from blood-borne bacteria or fungi Vegetations

  20. Topic 4: 4 points These are the consequences of shock The consequences are impaired tissue perfusion and cellular hypoxia

  21. Topic 4: 5 points This lesion in the maternal pulmonary microvasculature contains squamous cells, lanugo hair, fat from vernixcaseosa, and mucin Amniotic Fluid Embolism

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