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NCTR SCIENCE ADVISORY BOARD MEETING

NCTR SCIENCE ADVISORY BOARD MEETING. Biochemical Toxicology Program Update. Division Goals. Fundamental and applied research designed to define biological mechanisms of toxicity Assessment of carcinogenic risk Introduction of new techniques to assess carcinogenic risk. William H. Tolleson.

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NCTR SCIENCE ADVISORY BOARD MEETING

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  1. NCTR SCIENCE ADVISORY BOARD MEETING Biochemical Toxicology Program Update

  2. Division Goals • Fundamental and applied research designed to define biological mechanisms of toxicity • Assessment of carcinogenic risk • Introduction of new techniques to assess carcinogenic risk

  3. William H. Tolleson Mary D. Boudreau Dean W. Roberts Daniel R. Doerge K. Barry Delclos Paul C. Howard Sandra J. Culp Ming W. Chou S. Jill James Peter P. Fu Division Investigators Frederick A. Beland

  4. Extramural $816,000 Intramural $441,000 Division Discretionary Budget

  5. Division Research Areas • NIEHS/FDA IAG (NTP) • Neonatal mouse bioassay • Dietary folate/methyl deficiency • Analytical methods development

  6. NIEHS/FDA IAG (NTP) • Fumonisin B1 • Chloral hydrate • Urethane and ethanol • Malachite green • Endocrine disruptors • Phototoxicity • Dietary supplements • Anti-retroviral agents

  7. Endocrine Disruptors • Genistein, methoxychlor, nonyl-phenol, vinclozolin, and ethinyl estradiol • Range-finding studies • Multigeneration studies • Mechanistic studies • Collaborative studies

  8. Phototoxicity • - and -hydroxy acids • Aloe vera • Retinyl palmitate • Collaborative studies

  9. Dietary Supplements • Genistein • Riddelliine • Aloe vera

  10. Antiretroviral Agents • Perinatal exposures • AZT, 3TC, nevirapine, and nelfinavir • Carcinogenicity, genotoxicity, and metabolism

  11. Neonatal Mouse Bioassay • Benzodiazepines • Antihistamines • Lipid peroxidation products • Estrogens/antiestrogens • Proton pump inhibitors • Mycotoxins • Known human carcinogens • Antiretroviral agents

  12. Dietary Folate/Methyl Deficiency • Nucleotide pool imbalance and methylation dyregulation during hepatocarcinogenesis • Folate-dependent homocysteine metabolism • Methylene tetrahydrofolate reductase polymorphisms and Down syndrome

  13. Analytical Methods Development • Immunochemical methods - fumonisins, various DNA adducts, catechol estrogens • Liquid chromatography/mass spectrometry methods - genistein/daidzein, various DNA adducts

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