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ATL-Induced Apoptosis in MCL Z-138 Cell Line: Caspase Activation Mediation

This study investigates apoptosis in Z-138 cells induced by ATL, examining the role of caspase activation. The cells were treated with z-VAD-fmk, perifosine, or edelfosine, and apoptosis was quantified by flow cytometry. Data from three independent experiments are presented, showing significant differences compared to untreated control cells.

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ATL-Induced Apoptosis in MCL Z-138 Cell Line: Caspase Activation Mediation

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  1. ** ** ** ** Figure S3. ATL-induced apoptosis in the MCL Z-138 cell line is mediated by caspase activation. Z-138 cells were preincubated without (Control) or with 50 mM z-VAD-fmk for 1 h, and then in the absence (Control) or presence of 10 mM perifosine (PRIF) or edelfosine (EDLF) for 24 h. Apoptosis was quantitated as the percentage of cells in the sub-G0/G1 region following cell cycle analyses by flow cytometry. Data shown are means + SD of three independent experiments. Asterisks indicate values that are significantly different from untreated control cells at p < 0.01 (**) level by Student’s t-test.

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