1 / 16

Lymphangiectasia

Lymphangiectasia. Bill Lee Acc#: 106962. Case. “Maggie” 7 Yr, FS Yorkshire Terrier Lethargy, Inappetance Panhypoproteinemia (Albumin 1.1, Globulin 1.9) Hypocalcemia Hypocholesterolemia. Abdominal US. Mildly thickened SI walls: (duodenum: 5.7 mm, Jejunum: 5.0 mm)

lilike
Télécharger la présentation

Lymphangiectasia

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Lymphangiectasia Bill Lee Acc#: 106962

  2. Case • “Maggie” • 7 Yr, FS Yorkshire Terrier • Lethargy, Inappetance • Panhypoproteinemia (Albumin 1.1, Globulin 1.9) • Hypocalcemia • Hypocholesterolemia

  3. Abdominal US • Mildly thickened SI walls: (duodenum: 5.7 mm, Jejunum: 5.0 mm) • Multiple transverse SI mucosal linear hyperechogenicites • Thickened SI mucosal layer w/ mild loss of layer distinction (subjective) • Moderate anechoic peritoneal fluid (ascites)

  4. Abdominal US

  5. Abdominal US

  6. Abdominal US

  7. Abdominal US

  8. Histopathology • Sx biopsies: stomach, duodenum, jejunum, ileum • Duodenum: mod. lymphangiectasia and mod. lymphoplasmacytic enteritis • Jejunum, Ileum: mod. lymphangiectasia and mild lymphoplasmacytic enteritis

  9. Lymphangiectasia • Obstruction of lymphatics • Lymphatic dilation and rupture w/ loss of lymph (proteins, chylomicrons, lymphocytes) into int. lumen • Panhypoproteinemia – ascites, S.Q. edema, pleural fluid • Hypocholesterolemia • Lymphopenia

  10. Lymphangiectasia • Soft-coated Wheaten terriers, Basenjis, Yorkshire terriers, Norwegian Lundenhunds • Diarrhea, weight loss, vomiting, ascites, S.Q. edema, dyspnea (pleural fluid) • 1°/Congenital • Focal – S.I. only • Diffuse – Chylothorax, lymphedema, chyloabdomen • 2° • RCHF, Constrictive pericarditis, S.I. neoplasia (LSA), IBD

  11. Lymphangiectasia • Dx: endoscopy/laparotomy w/ histopath • Tx: oncotic support, low fat diet, Tx of 1° dz

  12. ULTRASONOGRAPHIC INTESTINAL HYPERECHOIC MUCOSALSTRIATIONS IN DOGS ARE ASSOCIATED WITH LACTEAL DILATIONVRUS 2007

  13. VRUS 2007 • Retrospective study, 23 dogs w/ SI hyperechoic mucosal striations and bx • Histopathologic lacteal dilation was present in 96% • Additional US findings: mild jej. wall thickening (96%), mild duod. wall thickening (78%), mucosal speckles (70%), and abd. effusion (87%) • Striations were diffuse (70%) or multifocal (30%) • No loss of wall layering, except in one dog with a severe mural lipogranuloma • Inflammatory infiltrates were mild (61%) or moderate (30%) • Chem. consistent with protein-losing enteropathy in 78%

  14. dilated mucosal villus lacteals (arrowhead)

  15. VRUS 2007 • Only 1 dog w/ striations but no evidence of lacteal dilation • Mild, multifocal interstitial villus edema with mild neutrophilic and eosinophilic villus inflammation

  16. Disseminated villus (interstitial and lymphatic) histiocytic sarcoma with marked lymphangiectasia (neoplastic cells within the dilated lymphatics)

More Related