1 / 7

Presented at European Society of Cardiology 2003

GRACIA-2 Trial. Primary Optimal Percutaneous Coronary Intervention versus Facilitated Intervention in STEMI patients. Presented at European Society of Cardiology 2003. GRACIA-2 Trial. 212 patients with acute ST elevation MI Presenting within 12 hours of symptom onset

lilith
Télécharger la présentation

Presented at European Society of Cardiology 2003

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. GRACIA-2 Trial Primary Optimal Percutaneous Coronary Intervention versus Facilitated Intervention in STEMI patients Presented at European Society of Cardiology 2003

  2. GRACIA-2 Trial 212 patients with acute ST elevation MI Presenting within 12 hours of symptom onset Enrolled at 15 centers in Spain and Portugal • Facilitated PCI • TNK bolus and enoxaparin immediately • Stent or CABG within 3-12 hours • (n = 104) • Optimal Primary PCI • PCI within 3 hours, with or without abciximab • (n = 108) • Endpoints (follow-up 6 months): • Primary – 1) Infarct size assessed by area under the curve for CKMB and troponin; 2) myocardial reperfusion by ST resolution at 1, 3, and 6 hours; and 3) LV angio at 6 weeks • Secondary – Death, MI, ischemic driven revascularization at 6 weeks and 6 months; Bleeding events European Society of Cardiology 2003

  3. GRACIA-2 Trial: Results • Trial designed to determine if facilitated PCI is as safe and effective as optimal primary PCI alone • Time from randomization to catheterization: • 1.08 hours in the primary PCI arm • 5.89 hours in the facilitated PCI arm • Infarct size similar in both groups, as was LV ejection fraction evolution at 6 weeks European Society of Cardiology 2003

  4. GRACIA-2 Trial: Epicardial Flow at Initial Angiography TIMI Frame Count p=0.034 TIMI Grade 3 Flow p=0.005 European Society of Cardiology 2003

  5. GRACIA-2 Trial: Complete ST Resolution 6 Hours p=0.03 3 Hours p=0.83 1 Hour p=0.19 European Society of Cardiology 2003

  6. GRACIA-2 Trial: Clinical Events and Bleeding Major Bleed p=0.97 Death / MI / Ischemic Driven Revascularization p=NS European Society of Cardiology 2003

  7. GRACIA-2 Trial • Angiographic data at initial angiography improved with facilitated PCI • Complete ST resolution at 6 hours improved with facilitated PCI • No increased bleeding with facilitated PCI • No significant difference in clinical outcomes, although sample size small (n=212) and underpwoered to show such a difference

More Related