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Prepared for the L aboratory for P roduct and P rocess D esign Created by Eric Lueshen

Prepared for the L aboratory for P roduct and P rocess D esign Created by Eric Lueshen Advisor: Andreas A. Linninger Presented on February 18, 2010. Research Update. Figure 2. Basic frame view (left) and pressure distribution (right) of validated simplified drug delivery model.

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Prepared for the L aboratory for P roduct and P rocess D esign Created by Eric Lueshen

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  1. Prepared for the Laboratory for Product and Process Design Created by Eric Lueshen Advisor: Andreas A. Linninger Presented on February 18, 2010 Research Update

  2. Figure 2. Basic frame view (left) and pressure distribution (right) of validated simplified drug delivery model. Pharmacokinetics/dynamics Program • Validation of steady state solutions • Linear Vasculature Program vs. Matlab Figure 1. Validated physiological pressures distributed throughout simplified drug delivery model.

  3. Steady State Equations • Linear algebra used to compute pressures • Flows calculated with Hagen–Poiseuille eqn A·x = b f = (1/α)·ΔP

  4. = Code Validation with Matlab Matlab solutions LVP solutions

  5. Generating Dynamic Equations F(1) = Vb(1)*(-(cb(1)-cbOld(1))/dt) + fl(11)*cb(11) - fl(2)*cb(1) - fl(5)*cb(1) - k(1)*cb(1)*Vb(1);

  6. Future Research • Finalize the code generation for dynamics • Physiological drug delivery models (rat & human) • Intrathecal drug delivery • Finish article draft with Dr. Alex

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