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This study explores the role of Smad3 in the kindling phenomenon observed in APC mutant Cdx+/- Muc-/- mice. Through targeted analysis, we investigate the underlying mechanisms and gene expression changes associated with this model. By examining the interactions between these genetic variations, we aim to enhance our understanding of the implications for neural activity and potential applications in treating related disorders. Our findings may shed light on the pathways involved in kindling and contribute to further research in this area.
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