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Synergistic Effects of FGFR4 Silencing with Chemotherapy in Colon Cancer Cells

This study investigates the role of FGFR4 silencing in enhancing chemotherapeutic efficacy in colon cancer cells. Supplementary Figure S1 demonstrates that FGFR4 silencing potentiates the effects of chemotherapy. Figure S2 reveals diminished STAT3 activity and decreased mRNA expression of anti-apoptotic proteins FLIP and Bcl-2 following FGFR4 knockdown. Additionally, Supplementary Figure S3 shows the impact of FGFR4 silencing on drug-resistant colon cancer cell lines. These findings highlight FGFR4 as a potential target for overcoming chemotherapy resistance in colon cancer treatment.

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Synergistic Effects of FGFR4 Silencing with Chemotherapy in Colon Cancer Cells

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  1. Supplementary Figure S1: FGFR4 silencing synergistically enhances the effects of chemotherapy in colon cancer cells. B A Neg Con FGFR4_2 siFGFR4 FGFR4_6 FGFR4 βActin C D

  2. Supplementary Figure S2: FGFR4 silencing decreasesSTAT3 activity and mRNA expression of FLIP and Bcl-2 A 2.5 5 10 Con B Neg Con FGFR4_2 siFGFR4 FGFR4_6 pSTAT3 tSTAT3 Actin C 24Hr 48Hr Con 2.5 5 10 BGJ398 (µM) pSTAT3 tSTAT3 GAPDH

  3. Supplementary Figure S3 FGFR4 silencing in drug resistant colon cancer cell lines. A HCT116 FUR OXR SNR Con Con OXA 5-FU Con 5-FU SN38 Con OXA 5-FU 5-FU OXA FGFR4 Actin

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