Glioblatomas are either: Primary - The patients develop it from the start

1. Glioblatomas are either: • Primary - The patients develop it from the start • Is the most common type of glioblastoma 2. Secondary • Progress from lower grades Note : Once the histologic features of glioblastoma appear, the prognosis is very poor; with treatment( resection , radiotherapy , and chemotherapy), the median survival is only 15 months

2. Note: Infatilepilocyticastrocytoma is called pilomyxoidastrocytomaand it is grade II typically located in the hypothalamus Morphology of pilocyticastrocytoma Gross: • Well circumscribed • Is often cystic, with a mural nodule in the wall of the cyst

3. Tumors that appear on MRI as cyst containing a nodule are: • Pilocyticastrocytoma • Ganglioglioma • PleomorphicXanthoastrocytoma

4. Microscopically,pilocyticastrocytoma - The tumor shows • Hypercellular areas composed of bipolar astrocytes with with long, thin "hairlike " processes that are GFAP positive • Hypocellular areas formed of microcysts. c. Rosenthal fibers d. Eosinophilic granular bodies, e. Necrosis and mitoses are absent. • Genetically Pilocyticastrocytomas don’t show mutations in IDH1 and IDH2

5. Pilocytic astrocytoma

6. Pilocyticastrocytoma

7. B. Oligodendroglioma - These tumors constitute about 5% to 15% of gliomas - Are most common in the fourth and fifth decades. - Patients may have had several years of neurologic complaints, often including seizures. - The lesions are found mostly in the cerebral hemispheres, mainly in the frontal or temporal lobes - Patients have better prognosis than astrocytomas of similar grade

8. Morphology Gross • Are infiltrative tumors • may show cysts, hemorrhage, and calcification. Note: Is the most common CNS tumor showing calcification On microscopic examination, 1. Grade II oligodendroglioma: • Is composed of sheets of regular cells with spherical nuclei containing fine chromatin • The nuclei are surrounded by a clear halo of cytoplasm

9. Grade II oligodendroglioma

10. - The tumor typically contains a delicate network of anastomosing capillaries. - Calcification, present in as many as 90% of these tumors, 2. Grade III anaplasticoligodendroglioma • Characterized by: • Significant mitotic activity(minimum criterion) • And/or microvascular proliferation • And/ or necrosis(geographic or pseudopalisading)

11. - Treatment with surgery, chemtherapy , and radiotherapy yield an average survival of 10-20 years for grade II and 5-10 years for grade III. - The most common genetic findings in oligodendrogliomas is 1p19q codeletion - Tumors with just those specific changes have a consistent and long-lasting response to chemotherapy

12. C. Ependymoma - Ependymomas most often arise next to the ependyma-lined ventricular system, including the central canal of the spinal cord. • In the first two decades of life a., they typically arise from floor of the fourth ventricle b. and constitute 5% to 10% of the primary brain tumors in this age group. • In adults, • the spinal cord is their most common location; and is considered as the most common type of glioma in the spinal cord in adults

13. tumors in this site (if multiple) are particularly frequent in the setting of neurofibromatosis type 2 Notes - May arise in the supratentorial region - The clinical outcome for completely resectedsupratentorial and spinal ependymomas is better than for those in the posterior fossa

14. Microscopically: 1. Grade II ependymomas • Are well circumscribed gliomas - Composed of cells with regular, round to oval nuclei • Between the nuclei there is a variably dense fibrillary background • Tumor cells may form: • Round or elongated structures ( Truerosettes,canals) that resemble the embryologic ependymal canal with long, delicate processes extending into a lumen

15. True Rosettes of ependymoma

16. Are specific to ependymoma • but are infrequent 2. Perivascular pseudo-rosettes • More frequently present • Not specific to ependymomas - Tumor cells are arranged around vessels with an intervening zone containing the ependymal processes .

17. Ependymoma

18. Perivascular pseudo rosettes

19. 2. Anaplasticependymomas (grade III) show : • Microvascular proliferation • Pseudopalisading necrosis Note:- Presence of geographic necrosis can be seen in grade II ependymomasand doesnt upgrade 3. Myxopapilllaryependymoma ( grade I ) • Arises in the filumterminale • and has good prognosis but tends to recur if not completely excised

20. II. Neuronal Tumors 1. Central neurocytoma(grade II) - Is a low-grade neuronal neoplasm • Found within and adjacent to the ventricular system (most commonly at the level of foramen of Munro) 2. Gangliogliomas - Are tumors with a mixture of glial elements (looking like a low-grade astrocytoma) and mature-appearing neurons. • Most of these tumors are slowly growing, - These lesions often present with seizures

21. Embryonal primitive neoplasms - The most common is the medulloblastoma, accounting for 20% of pediatric brain tumors. Medulloblastoma (WHO grade IV) • occurs predominantly in children • and exclusively in the cerebellum. - The tumor is highly malignant, • The prognosis for untreated patients is dismal - It is radiosensitive - With total excision and radiation, the 5-year survival rate may be as high as 75%.

22. . - Tumors of similar histology can be found elsewhere in the nervous system (called CNS primitive neuroectodermaltumor, or CNS PNET ) Morphology - In children, medulloblastomas are located in the midline of the cerebellum (vermis) but may extend to the surface of the cerebellar folia and involving the leptomeninges - Lateral tumors (in cerebellar hemispheres) occur more often in adults.

23. Microscopically a. Are extremely cellular, with sheets of anaplastic ("small blue") cells b. Individual tumor cells are small, with little cytoplasm and hyperchromatic nuclei; • Mitoses are abundant. • May show Homer-wrightrosettes as evidence of neuronal differentiation

24. Medulloblastoma

25. medulloblastoma

26. IV. Primary Central Nervous System Lymphoma • Accounts for 1% of intracranial tumors. A- It is the most common CNS neoplasm in immunosuppressed individuals (including transplant recipients and persons with AIDS); under these circumstances the CNS lymphomas are nearly all driven by Epstein-Barr virus and show necrosis B. In non-immunosuppressed populations, the age spectrum is relatively wide, with the incidence increasing after 60 years of age; - Most of these tumors are diffuse large B-cell lymphomas

27. - Regardless of the clinical context, primary brain lymphoma is an aggressive disease with relatively poor response to chemotherapy as compared with peripheral lymphomas - Individuals with primary brain lymphoma often have multiple sites of tumor within the brain parenchyma; -. Lymphoma arising outside the CNS rarely involves the brain parenchyma; when it does occur, there is usually tumor within the CSF and around intradural nerve roots -

28. V. Germ cell tumors - Primary brain germ-cell tumors occur commonly in: A. Pineal region B. suprasellar region - 90% occur during the first two decades of life - CNS involvement by a gonadal germ-cell tumor is not uncommon

29. VI. Meningiomas : - They occur in adults - Are predominantly benign tumors that arise from arachnoid cap cells and attached to the dura. - May be found along any of the external surfaces of the brain as well as within the ventricular system, where they arise from the arachnoid cells of the choroid plexus. - Clinically they either present with vague non-localizing symptoms, or with focal findings referable to compression of adjacent brain.

30. - Although most meningiomas are easily separable from underlying brain, some may infiltrate the brain, a feature that is associated with an increased risk of recurrence - The overall prognosis is determined by the location, surgical accessibility, and histologic grade. - When a person has multiple meningiomas,with bilateral vestibular schwannomas or spinal ependymoma, the diagnosis of NF2 syndrome should be considered

31. - About half of meningiomas not associated with NF2 have acquired loss-of-function mutations in the NF2 tumor suppressor gene on the long arm of chromosome 22 . - These mutations are found in all grades of meningioma,. - NF2 mutations are more common in tumors of certain patterns (fibroblastic, transitional, psammomatous).

32. Gross-: WHO grade I grow as well-defined dura-based masses that may compress the brain but do not invade it and extension into the overlying bone may be present and does not upgrade the tumor to grade II. Microscopic : • Oval cells with indistinct borders and • Intranuclearpseudoinclusions • arranged in syncytia with whorling

33. Meningioma

34. Meningeoma

35. Grade I • No more than 3 MF/10HPF 2. Grade II meningeomaare recognized by either: A. Mitotic figures of more than 3 but less than 20 per 10 HPF(high power fields) B. Or presence of 3 of the following 5 atypical features 1. Small cells, 2. Prominent nucleoli , 3. Sheeting 4. Hypercellularity, 5. Spontaneous necrosis not induced by embolization

36. C. Or Brain invasion D. Clear or chordoid variants - These tumors are more aggressive with a higher rate of recurrence and may require radiation therapy in addition to surgery 3. Anaplastic (malignant) meningiomas (WHO grade III) - Are highly aggressive tumors characterized by either: a. They resemble a high-grade sarcoma or carcinoma or melanoma b. Or Mitotic figures of 20 or more per 10HPF(high power fields) c. Papillary or rhabdoid variants

37. VII. Metastatic Tumors - The most common primary sites are lung, breast, skin (melanoma), kidney, and gastrointestinal tract- - Metastases form sharply demarcated masses, often at the gray-white junction, and elicit marked edema - The boundary between tumor and brain parenchyma is sharp at the microscopic level as well

38. CNS manifestaions of Familial Tumor Syndromes I. Tuberous Sclerosis :- Is an autosomal dominant syndrome characterized by a. The development of CNS hamartomas consist of: Cortical tubers which are associated with seizures and can be difficult to control with antiepileptic drugs. b. Benign brain neoplasms such as subependymal giant cell astrocytomaand because of their proximity to the

39. foramen of Monro, they present acutely with obstructive hydrocephalus, which requires surgical intervention 2. von Hippel-Lindau Disease: - An autosomal dominant - The CNS tumor is hemangioblastoma (grade I) Hemangioblastomasinsporadic cases occur in the cerebellar hemispheres and spinal cord In von Hippel-Lindau Disease: , tend to occur as multiple lesions in the spinal cord

40. Paraneoplastic syndromes affecting the brain 1. Subacutecerebellar degeneration - Resulting in ataxia, with destruction of Purkinje cells, 2. Limbic encephalitis: - Causing a subacute dementia, - Charcterized by perivascular inflammatory cells, some neuronal loss, and gliosis, in the medial temporal lobe

41. 3. Syndrome of rapid-onset psychosis, epilepsy, and coma - Associated with ovarian teratoma and antibodies against the N-methyl-d-aspartate (NMDA) receptor