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Analysis of SR Moiety Shifts and Electrophysiological Measurements in Dibas et al. Study

This document discusses key findings from the study by Dibas et al., particularly focusing on the analysis of the SR (substrate-responsive) moiety behavior in relation to linker structures and their electrophysiological implications (measured in μA) under varying conditions. The significance of highlighting specific amino acids like Leu264 in the context of the linker’s influence is emphasized. Detailed figures are referenced, showcasing shifts in current and fluorescence changes, pertinent to the study's conclusions on SR functionality and structural configurations.

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Analysis of SR Moiety Shifts and Electrophysiological Measurements in Dibas et al. Study

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  1. 11/26/06 Dibas et al., Figure

  2. 11/26/06 Dibas et al., Figure

  3. 11/26/06 Dibas et al., Figure

  4. 5 s b19’CSR-L16'F 1 mM ACh MTSR MTSR TAMRA 5 s 5 μA 2 μA F0 was 7.2 V 3 % 5 % ΔF Dibas et al., Figure

  5. Mohammed please generate this figure 11/26/06 Dibas et al., Figure

  6. 11/26/06 Dibas et al., Figure

  7. This is Henry’s error; we should highlight Leu264 Also this picture excludes the linker. When the linker is included, the SR moiety could shift “down”, centering with regard to Val291 and Leu264. 11/26/06 Dibas et al., Figure

  8. A C B D 11/26/06 Dibas et al., Figure

  9. ΔI 5 μA ΔF 5 % 5 s 11/26/06 Dibas et al., Figure

  10. 11/26/06 Dibas et al., Figure

  11. 11/26/06 Dibas et al., Figure

  12. 11/26/06 Dibas et al., Figure

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