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International School of Engineers

International School of Engineers. Second Assembly of the RCI: 21st to 24th November 2007 in Forbach. Dolly Montoya C, PhD, MSc,. www. ibun.unal.edu.co. Engineering in Biotechnology- Biotechnology in Engineering Structure. Introduction Biotechnology Innovation strategies

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International School of Engineers

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  1. International School of Engineers Second Assembly of the RCI: 21st to 24th November 2007 in Forbach Dolly Montoya C, PhD, MSc, Dolly Montoya C. Universidad Nacional de Colombia. www. ibun.unal.edu.co

  2. Engineering in Biotechnology- Biotechnology in EngineeringStructure • Introduction • Biotechnology Innovation strategies • The overall strategy for developing biotechnology • New needs in Engineering for developing biotechnology • Multilateral network for increasing biotechnology's competitiveness and a proposal for future developments Dolly Montoya C. Universidad Nacional de Colombia.

  3. Introduction Dolly Montoya C. Universidad Nacional de Colombia.

  4. International School of Engineers proposal from Metz School of Engineers Cartagena Network Gesticon PUEDE (University Enterprise for development programme) International School of Engineers Dolly Montoya C. Universidad Nacional de Colombia.

  5. 2. Biotechnology Innovation strategies Dolly Montoya C. Universidad Nacional de Colombia.

  6. Innovation life-cycles We have been given an opportunity to become part of the development of a new world economy via interdisciplinary innovation Dolly Montoya C. Universidad Nacional de Colombia.

  7. Biotechnology This is a group of techniques using live organisms or substances coming from such organisms for: making or modifying a product; improving plants or animals; and developing microorganisms for specific uses Dolly Montoya C. Universidad Nacional de Colombia.

  8. Biotechnology Characteristics • It is knowledge or “know-how” intensive • It is interdisciplinary • Traditional processes are upgraded using current biotechnology • It embraces different production sectors Dolly Montoya C. Universidad Nacional de Colombia.

  9. Biotechnology is interdisciplinary Biology and Pure Science Law and Political Science Biotechnology Economics Engineering Human science Dolly Montoya C. Universidad Nacional de Colombia.

  10. Industrial sectors influenced by biotechnology Pharmaceutical biotechnology New substances New raw materials Dolly Montoya C. Universidad Nacional de Colombia. Wastewater treatment Industrial biotechnology

  11. Biotechnology’s products • Methane, ethanol, biodiesel, biomass, waste water purification, residue treatment, amino acids, organic acids, foods, acetone, buthanol, yeasts, polymers, etc Traditional biotechnology High-volume and low-value • Products obtained by genetic manipulation, gene and non-gene therapy, genetically modified plants Biotechnology in the era of genetic engineering Low-volume and high-value Transcriptomics, proteomics, metabolomics, bioinformatics and nanobiotechnology Biotechnology in the post-genomic era Using highly complex computational models for designing and constructing metabolic pathways or even partially or totally synthetic microorganisms Biología sintética Synthetic biology: the future Dolly Montoya C. Universidad Nacional de Colombia.

  12. Biotechnology Innovation strategies • Knowledge is the key to sustainable growth; however, investment in research and development (R&D) is not enough for producing innovation. We can only talk of innovation if it is accompanied by economic growth and social wellbeing. Dolly Montoya C. Universidad Nacional de Colombia.

  13. Biotechnology Innovation strategies • Knowledge (know-how) • Skills development • Promoting a setting for innovation • Strengthening an innovative community Dolly Montoya C. Universidad Nacional de Colombia.

  14. Transforming higher education represents a challenge for the present Dolly Montoya C. Universidad Nacional de Colombia.

  15. Long-term view The university’s long-term view must take the national and international setting into consideration: The changing international setting • International treaties and interdependent relationships. • New relationships and changing roles between university-company-state, new actors. • Widening the economic and technological breach between countries and regions. Regarding the challenges of biotechnology New paradigms for the society of knowledge (know-how) • Educational: the university’s new role as a producer of know-how companies. • Technological: investment in technological development multiplies economic development. • Organisational: using strategic thinking for resolving complex problems. Ongoing innovation in all areas. • Social: knowledge reduces the social gap and produces wellbeing. Dolly Montoya C. Universidad Nacional de Colombia.

  16. Transforming higher education represents a challenge for the present University Feedback Pedagogical process Society Knowledge • Teaching • Investigation • Extension Interdisciplinary Dolly Montoya C. Universidad Nacional de Colombia.

  17. 3.0 The overall strategy for developing BiotechnologyEngineering in Biotechnology- Biotechnology in Engineering Dolly Montoya C. Universidad Nacional de Colombia.

  18. The overall strategy for developing Biotechnology • Developing the ability to formulate strategic plans • Subscribing to modern management techniques • Strengthening entrepreneurial decision-making • Developing an educational policy aimed at biotechnological education/training Dolly Montoya C. Universidad Nacional de Colombia.

  19. Engineering in Biotechnology- Biotechnology in Engineering 4.0 New needs in Engineering for developing BiotechnologyEngineering’s contribution to the future of Biotechnology Dolly Montoya C. Universidad Nacional de Colombia.

  20. The cell Red Biotechnology Human Biotechnology White Biotechnology Industrial Chemistry Biotechnology Green Biotechnology Agriculture Biotechnology Dolly Montoya C. Universidad Nacional de Colombia.

  21. Engineering’s contribution totraditional biotechnology Isolation and characterisation Laboratory Scaling-up • Non-structured growth kinetics models • Blended and oxygenation kinetics in reactors • Instrumentation and control systems in bioprocess • Enzyme immobilisation • Bioreactor design • Cellular protein production • Support devices: • Orbital shakers, • Refrigerators, • Anaerobic and aerobic incubators, • Anaerobic chambers, • pH meters, etc Dolly Montoya C. Universidad Nacional de Colombia.

  22. Engineering’s contribution to biotechnology in the era of genetic engineering Isolation, characterisation and gene modification Laboratory Scaling-up • New technologies: • Recombinant DNA • Hybridome technology • Cell culturing • DNA and protein sequencing • Bioremediation • Metabolic engineering • Molecular modelling • Protein chromatography • New separation processes: nanofiltration, ultrafiltration, molecular sieves, supercritical fluid extraction, azeotropic distillation, etc Dolly Montoya C. Universidad Nacional de Colombia.

  23. Probing microbial communities at environmental, community, cellular, sub-cellular and molecular levels Dolly Montoya C. Universidad Nacional de Colombia.

  24. Dolly Montoya C. Universidad Nacional de Colombia.

  25. Dolly Montoya C. Universidad Nacional de Colombia.

  26. Synthetic Biology • Traditional Biochemistry and molecular research methods to involve to a degree of maturity and they can used for redesigned live cells, biochemical interaction and metabolic routes. • Rapid DNA synthesis must also used for constructing artificial genes and operons, leading to thinking about completely sythetic live organisms Dolly Montoya C. Universidad Nacional de Colombia.

  27. The Biotechnology of the first half of the 21st century must face great challenges 20th century: post-genomic era and the search for structures Genomic, Proteomic, Metabolomic, Transcriptomic The cell as the sum of its parts 21st century: deep understanding of biological systems ensuring their efficient use Synthetic biology Bioinformatics, systems and control theories, complex mathematical models, computational simulation, robotics, mechatronics, etc. Dolly Montoya C. Universidad Nacional de Colombia.

  28. 5.0 Multilateral network for increasing biotechnology's competitiveness and a proposal for future developments Engineering in Biotechnology-Biotechnology in Engineering Dolly Montoya C. Universidad Nacional de Colombia.

  29. Proposal for cooperative work Biotechnological core process (BCP) Organisation: the Biotechnology Network (BIONET) • Highly qualified scientists and professionals in areas related to biotechnology • Physical infrastructure • R&D interaction • Developing prototypes with enterprises • Ongoing evaluation • Biobusiness Dolly Montoya C. Universidad Nacional de Colombia.

  30. Immediate tasks • We have to know whom we are going to work with in biotechnology and engineering (establishing the network) • The areas of interest in biotechnology must be defined and clearly focused • A coherent strategic plan must be drawn up • Specific projects must be defined Dolly Montoya C. Universidad Nacional de Colombia.

  31. Biotechnological core process (BCP) Ongoing evaluation Scientists, technicians and highly qualified professionals Biobusiness Prototype development with companies Infrastructure R&D interaction Dolly Montoya C. Universidad Nacional de Colombia.

  32. The Institute of Biotechnology at the Universidad Nacional de Colombia • An organisation which learns • University - business relationship Dolly Montoya C. Universidad Nacional de Colombia.

  33. Business Dolly Montoya C. PhD Instututo de Biotecnología Points of rapprochement in University – Business Incubator - CDT University Links for technological development and prototypes Production and sales Knowledge Evaluating national and international ideas regarding products and services Industrial scaling-up Producing new ideas Defining intellectual property Accompaniment in negotiation Defining standards for biosafety and the environment Market niches Business plans Establishing ethical and legal standards Dolly Montoya C. Universidad Nacional de Colombia.

  34. From the laboratory to industry Bioprospecting: consolidating the system in the search for desired biological activities Establishing criteria for defining promising activities in each case Sustainable exploitation of biodiversity and genetic resources If necessary, improving strains via metabolic engineering or genetic transformation Preliminary technical-economic evaluation Taxonomic definition of species by biochemical and molecular characterisation Fermentation at bank level Drawing up a business plan from the fermentation results If proving viable, Initiating the patenting process Seeking a partner for scaling-up the process at pilot-plant level Industrial development Dolly Montoya C. Universidad Nacional de Colombia.

  35. Solventogenics Rubber Yeasts Biofertilisers and PHAs Bioprospecting Solventogenics Rubber Yeasts Biofertilisers and PHAs Bioprocesses and Bioprospecting groups What do we do in common? Fermentation and Enzyme laboratories Microbiology laboratory Solventogenics Rubber Yeasts Biofertilisers and PHAs Molecular and enzymatic characterisation Fermentation IBUN biofertilisers MAVALLE rubber Pilot-plant PROCAPS yeasts Dolly Montoya C. Universidad Nacional de Colombia.

  36. must be characterised Isolatingsolventogenic Clostridia 155 soil samples 178 Clostridia isolates 13 promising strains Dolly Montoya C. Universidad Nacional de Colombia.

  37. Biodiesel Ácidos grasos GLICEROL Bioprospecting for 1,3 propanodiol production Dolly Montoya C. Universidad Nacional de Colombia.

  38. Biopolymer bioprospecting Characterisation Soil Isolation Strain Fermentation Obtaining enzyme Milling and packaging Drying Precipitation Dolly Montoya C. Universidad Nacional de Colombia. Reacting

  39. SIVAN biopolymer production pilot-plant Dolly Montoya C. Universidad Nacional de Colombia.

  40. Bringing on line Recuperation Fermentation reaction Precipitation Drying Receiving the polymer Dolly Montoya C. Universidad Nacional de Colombia.

  41. Biofertiliser production pilot-plant Dolly Montoya C. Universidad Nacional de Colombia.

  42. Dimargon Registro ICA No 4716 Trifesol Dimazos Registro ICA No 4718 Fosfosol Registro ICA No 4717 Selecting micro-organisms Producing the active ingredient Field validation trials Formulating Packaging Biofertilisers and Biocontrollers Mention of honour in the First National Competition for Projects in Agribusiness Biotechnology having entrepreneurial potential The dose of nitrogen and phosphor from inorganic sources applied to rice crops was reduced by 35% with consequently reduced costs, thereby improving the crop’s profitability Containing micro-organisms which increase nutrient supply and availability, thereby improving soil fertility level and contributing towards plant growth The products so formulated have been initially tested on 40,000 hectares sown with rice and cotton Dolly Montoya C. Universidad Nacional de Colombia. Pilot-plant (100 and 1,000L)

  43. Thank you for your kind attention E-mail: dmontoyac@gmail.com Dolly Montoya C. Universidad Nacional de Colombia.

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