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Hierarchical Clustering Reveals Distinct Subclusters in Muscle-Invasive TCC Tumors Impacting Survival

This study utilizes unsupervised hierarchical clustering to analyze 47 muscle-invasive transitional cell carcinoma (TCC) tumors, identifying three distinct subclusters. Notably, one subcluster comprising 11 tumors exhibited significantly short overall survival (median 5.4 months), while the other two contained a mix of tumors with varied survival outcomes (median 16.7 and 19.3 months). Kaplan-Meier survival analysis indicated a significant association between tumor groupings and patient outcomes, demonstrating the prognostic relevance of tumor classification in TCC.

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Hierarchical Clustering Reveals Distinct Subclusters in Muscle-Invasive TCC Tumors Impacting Survival

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  1. p= 6.92e-06 Outcome based on groups of tumors identified by hierarchical clustering Left side: Unsupervised Hierarchical clustering of 47 muscle-invasive TCC tumors resulted in the distinct separation of these tumors into 3 subclusters. One of these subclusters contained 11 tumors with very short overall survival (median 5.4 months) while the remaining two subclusters contained a mixture of both short and long survival tumors (median 16.7 and 19.3 months). This tumor dendrogram is identical to that shown in Supplemental data: Unsupervised.muscle-invasive.Right side: Kaplan-Meier survival analysis showed significant association with outcome when performed based on these tumor groups.

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